Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ESR1 | P03372 | 2/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ESRRA | P11474 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30367422 | 0.81 | LMNA (0.51) | METAP2LMNAKDM4EKMT2AMEN1 | |
| SCHEMBL22923858 | 0.79 | LMNA (0.49) | LMNAKDM4EKMT2AESR1ESR2 | |
| SCHEMBL22923879 | 0.79 | LMNA (0.49) | METAP2LMNAKDM4EKMT2AMEN1 | |
| SCHEMBL23147528 | 0.76 | NOTUM (0.46) | METAP2LMNAKDM4EKMT2AMEN1 | |
| SCHEMBL22923863 | 0.76 | LMNA (0.52) | LMNAKDM4EKMT2AESR1ESR2 | |
| SCHEMBL21776536 | 0.75 | LMNA (0.48) | METAP2LMNAKDM4EKMT2AMEN1 | |
| SCHEMBL5381779 | 0.75 | LMNA (0.45) | LMNAKDM4EKMT2AMEN1L3MBTL1 | |
| SCHEMBL22923842 | 0.75 | LMNA (0.45) | LMNAKDM4EKMT2AMEN1L3MBTL1 | |
| SCHEMBL22923941 | 0.74 | MAPT (0.38) | METAP2LMNAKDM4EKMT2AMEN1 | |
| SCHEMBL23147394 | 0.73 | LMNA (0.46) | METAP2LMNAKDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021012717-A1 | ANTITUMOR COMPOUND USED AS AXL INHIBITOR AND USE THEREOF | 南京华威医药科技集团有限公司 | 2021-01-28 | — | — | WO | disclosed |