Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 7/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | SENP7 | Q9BQF6 | 5/20 | 0.54 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.53 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | SENP8 | Q96LD8 | 3/20 | 0.52 |
| ▸ | SENP6 | Q9GZR1 | 3/20 | 0.52 |
| ▸ | CASP3 | P42574 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3349880 | 0.80 | HTT (0.72) | HTTHPGDPTGS2MAPTMEN1 | |
| SCHEMBL15930268 | 0.80 | HTT (0.72) | HTTHPGDPTGS2MAPTMEN1 | |
| SCHEMBL1643902 | 0.77 | HTT (0.68) | HTTHPGDPTGS2MAPTMEN1 | |
| SCHEMBL2189141 | 0.77 | HTT (1.00) | HTTHPGDPTGS2MAPTMEN1 | |
| SCHEMBL1643903 | 0.77 | HTT (0.68) | HTTHPGDPTGS2MAPTMEN1 | |
| SCHEMBL2189137 | 0.77 | HTT (1.00) | HTTHPGDPTGS2MAPTMEN1 | |
| SCHEMBL13622497 | 0.77 | HTT (0.68) | HTTHPGDPTGS2MAPTMEN1 | |
| SCHEMBL5167169 | 0.77 | HTT (1.00) | HTTHPGDPTGS2MAPTMEN1 | |
| SCHEMBL31355128 | 0.77 | HTT (1.00) | HTTHPGDPTGS2MAPTMEN1 | |
| SCHEMBL29786168 | 0.77 | HTT (0.68) | HTTHPGDPTGS2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11066410-B2 | Fused triazolo-pyrimidine compounds having useful pharmaceutical application | 3100 CENTRAL EXPRESSWAY LLC (US) | 2021-07-20 | — | — | US | disclosed |
| WO-2021012264-A1 | TRIAZOLE SULFONAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 东莞市东阳光农药研发有限公司 | 2021-01-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11066410-B2 | Fused triazolo-pyrimidine compounds having useful pharmaceutical application | PIKFYVE, PIP4K2B, PIP4K2A | HTT 2855/4885HPGD 4401/4885PTGS2 4363/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.