Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | CPS1 | P31327 | 2/20 | 0.38 |
| ▸ | FASN | P49327 | 2/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17389928 | 0.88 | FASN (0.49) | MAPTRXFP1CPS1FASNHTT | |
| SCHEMBL16150924 | 0.83 | RXFP1 (0.44) | MAPTRXFP1CPS1FASNGBA1 | |
| SCHEMBL16149873 | 0.80 | RXFP1 (0.40) | MAPTRXFP1CPS1FASNGBA1 | |
| Hydrochloric Acid SCHEMBL17389942 | 0.79 | RXFP1 (0.43) | MAPTRXFP1CPS1 | |
| SCHEMBL28497720 | 0.79 | CPS1 (0.39) | MAPTRXFP1CPS1FASNGBA1 | |
| SCHEMBL16150156 | 0.76 | MAPT (0.36) | MAPTRXFP1CPS1FASNHTT | |
| SCHEMBL16150679 | 0.73 | FASN (0.64) | MAPTRXFP1FASNHTTKDM4E | |
| SCHEMBL23641648 | 0.73 | RXFP1 (0.45) | MAPTRXFP1FASNTP53 | |
| SCHEMBL22926218 | 0.71 | FASN (0.51) | MAPTRXFP1FASNTSHRALDH1A1 | |
| SCHEMBL22926335 | 0.69 | SMN1; SMN2 (0.42) | MAPTRXFP1TSHRTP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3587406-B1 | 2-HYDROXY-1-{4-[(4-PHENYLPHENYL)CARBONYL]PIPERAZIN-1-YL}ETHAN-1-ONE DERIVATIVES AND RELATED COMPOUNDS AS FATTY ACID SYNTHASE (FASN) INHIBITORS FOR THE TREATMENT OF CANCER | FORMA THERAPEUTICS INC (US) | 2021-01-27 | — | — | EP | disclosed |