Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 16/20 | 0.58 |
| ▸ | JAK3 | P52333 | 6/20 | 0.51 |
| ▸ | AURKA | O14965 | 2/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.51 |
| ▸ | PAK4 | O96013 | 2/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.51 |
| ▸ | CSF1R | P07333 | 2/20 | 0.51 |
| ▸ | RET | P07949 | 2/20 | 0.51 |
| ▸ | IGF1R | P08069 | 2/20 | 0.51 |
| ▸ | MET | P08581 | 2/20 | 0.51 |
| ▸ | PIM1 | P11309 | 2/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.51 |
| ▸ | PRKACA | P17612 | 2/20 | 0.51 |
| ▸ | FLT1 | P17948 | 2/20 | 0.51 |
| ▸ | LTK | P29376 | 2/20 | 0.51 |
| ▸ | GRK5 | P34947 | 2/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13286408 | 0.78 | AURKA (0.62) | JAK2JAK3AURKADAPK3PRKD3 | |
| SCHEMBL30589328 | 0.78 | AURKA (0.62) | JAK2JAK3AURKADAPK3PRKD3 | |
| SCHEMBL27868341 | 0.76 | JAK2 (0.55) | JAK2JAK3AURKADAPK3PRKD3 | |
| SCHEMBL27868344 | 0.76 | JAK2 (0.48) | JAK2JAK3AURKADAPK3PRKD3 | |
| SCHEMBL13878218 | 0.76 | JAK2 (0.67) | JAK2JAK3AURKADAPK3PRKD3 | |
| SCHEMBL4582353 | 0.74 | JAK2 (0.70) | JAK2JAK3AURKADAPK3PRKD3 | |
| SCHEMBL4006751 | 0.74 | JAK2 (1.00) | JAK2JAK3AURKADAPK3PRKD3 | |
| SCHEMBL101810 | 0.73 | JAK2 (0.53) | JAK2JAK3AURKADAPK3PRKD3 | |
| SCHEMBL27762575 | 0.73 | JAK2 (0.44) | JAK2JAK3AURKADAPK3PRKD3 | |
| SCHEMBL13695723 | 0.72 | JAK2 (0.65) | JAK2JAK3RETPRKACAROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3466953-B1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE AS JANUS KINASE INHIBITOR | INCYTE HOLDINGS CORP (US) | 2021-02-03 | — | — | EP | disclosed |