Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 17/20 | 0.44 |
| ▸ | JAK1 | P23458 | 13/20 | 0.44 |
| ▸ | JAK3 | P52333 | 8/20 | 0.44 |
| ▸ | TYK2 | P29597 | 5/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | MERTK | Q12866 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 4/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.43 |
| ▸ | PAK4 | O96013 | 3/20 | 0.43 |
| ▸ | LTK | P29376 | 3/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.43 |
| ▸ | CLK2 | P49760 | 3/20 | 0.43 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.43 |
| ▸ | IKBKE | Q14164 | 3/20 | 0.43 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.43 |
| ▸ | CAMK1D | Q8IU85 | 3/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27868344 | 0.86 | JAK2 (0.48) | JAK2JAK1JAK3TYK2AXL | |
| SCHEMBL27741971 | 0.81 | JAK2 (0.59) | JAK2JAK1JAK3TYK2AXL | |
| SCHEMBL101810 | 0.81 | JAK2 (0.53) | JAK2JAK1JAK3TYK2AXL | |
| SCHEMBL17227592 | 0.77 | JAK2 (0.49) | JAK2JAK1JAK3TYK2AXL | |
| SCHEMBL101138 | 0.76 | AXL (0.49) | JAK2JAK1JAK3TYK2AXL | |
| SCHEMBL21316579 | 0.76 | AXL (0.49) | JAK2JAK1JAK3TYK2AXL | |
| SCHEMBL171699 | 0.76 | AXL (0.49) | JAK2JAK1JAK3TYK2AXL | |
| SCHEMBL12506701 | 0.74 | AXL (0.48) | JAK2JAK1JAK3TYK2AXL | |
| SCHEMBL22930855 | 0.73 | JAK2 (0.58) | JAK2JAK1JAK3TYK2RET | |
| SCHEMBL12250906 | 0.72 | JAK2 (0.61) | JAK2JAK1JAK3TYK2AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103254190-A | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors | INCYTE CORP | 2013-08-21 | — | — | CN | disclosed |
| CN-101448826-A | Heteroaryl substituted pyrrolo [2 ] as janus kinase inhibitors | INCYTE CORP (US) | 2009-06-03 | — | — | CN | disclosed |