Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 4/20 | 0.38 |
| ▸ | JAK1 | P23458 | 3/20 | 0.38 |
| ▸ | TYK2 | P29597 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 3/20 | 0.35 |
| ▸ | NUDT1 | P36639 | 4/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.35 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.35 |
| ▸ | AKT2 | P31751 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 4/20 | 0.35 |
| ▸ | ATRIP | Q8WXE1 | 3/20 | 0.35 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.33 |
| ▸ | CCNK | O75909 | 2/20 | 0.32 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | PRKCA | P17252 | 1/20 | 0.31 |
| ▸ | PRKACA | P17612 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL99826 | 0.77 | PRKCI (0.44) | PRKCIJAK2JAK1TYK2JAK3 | |
| SCHEMBL29540628 | 0.77 | PRKCI (0.44) | PRKCIJAK2JAK1TYK2JAK3 | |
| SCHEMBL21974724 | 0.76 | PRKCI (0.41) | PRKCIJAK2JAK1TYK2JAK3 | |
| SCHEMBL29540881 | 0.74 | BRD4 (0.46) | PRKCIJAK2JAK3NUDT1AURKB | |
| SCHEMBL99271 | 0.74 | BRD4 (0.46) | PRKCIJAK2JAK3NUDT1AURKB | |
| SCHEMBL16692485 | 0.73 | PRKCI (0.48) | PRKCIJAK2JAK3NUDT1AURKA | |
| SCHEMBL98273 | 0.73 | AURKB (0.56) | PRKCIJAK2JAK3NUDT1AURKA | |
| SCHEMBL29540441 | 0.73 | AURKB (0.56) | PRKCIJAK2JAK3NUDT1AURKA | |
| SCHEMBL29541013 | 0.72 | PRKCI (0.47) | PRKCIJAK2JAK3NUDT1AURKA | |
| SCHEMBL100065 | 0.72 | PRKCI (0.47) | PRKCIJAK2JAK3NUDT1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3838903-B1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE AS JANUS KINASE INHIBITOR | INCYTE HOLDINGS CORP (US) | 2023-11-22 | — | — | EP | disclosed |
| EP-3466953-B1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE AS JANUS KINASE INHIBITOR | INCYTE HOLDINGS CORP (US) | 2021-02-03 | — | — | EP | disclosed |