Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 1/20 | 0.38 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.35 |
| ▸ | CIT | O14578 | 4/20 | 0.34 |
| ▸ | NUDT1 | P36639 | 3/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.34 |
| ▸ | AURKA | O14965 | 3/20 | 0.34 |
| ▸ | INCENP | Q9NQS7 | 3/20 | 0.34 |
| ▸ | MET | P08581 | 3/20 | 0.34 |
| ▸ | LYN | P07948 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.34 |
| ▸ | AKT2 | P31751 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL98969 | 0.81 | CIT (0.48) | CITAURKBAURKAINCENPMET | |
| SCHEMBL29540640 | 0.81 | CIT (0.48) | CITAURKBAURKAINCENPMET | |
| SCHEMBL21974724 | 0.81 | PRKCI (0.41) | PRKCIPBKNUDT1AURKBAURKA | |
| SCHEMBL15427363 | 0.75 | PRKCI (0.41) | PRKCIPBKNUDT1AURKBAURKA | |
| SCHEMBL29540441 | 0.72 | AURKB (0.56) | PRKCICITNUDT1AURKBAURKA | |
| SCHEMBL16692485 | 0.72 | PRKCI (0.48) | PRKCICITNUDT1AURKBAURKA | |
| SCHEMBL98273 | 0.72 | AURKB (0.56) | PRKCICITNUDT1AURKBAURKA | |
| SCHEMBL29541013 | 0.71 | PRKCI (0.47) | PRKCIPBKCITNUDT1AURKB | |
| SCHEMBL100065 | 0.71 | PRKCI (0.47) | PRKCIPBKCITNUDT1AURKB | |
| SCHEMBL18602200 | 0.71 | PRKCI (0.55) | PRKCIPBKNUDT1AURKBAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3466953-B1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE AS JANUS KINASE INHIBITOR | INCYTE HOLDINGS CORP (US) | 2021-02-03 | — | — | EP | disclosed |