Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD38 | P28907 | 8/20 | 0.70 |
| ▸ | ADORA2A | P29274 | 11/20 | 0.56 |
| ▸ | ADORA2B | P29275 | 7/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22946910 | 0.83 | CD38 (1.00) | CD38 | |
| SCHEMBL31484489 | 0.83 | CD38 (1.00) | CD38 | |
| SCHEMBL22933540 | 0.81 | CD38 (0.73) | CD38KDM4ETSHRHTT | |
| SCHEMBL25474644 | 0.73 | CD38 (0.50) | CD38KDM4ETSHRHTT | |
| SCHEMBL22936148 | 0.73 | CD38 (0.74) | CD38ADORA2AADORA2B | |
| SCHEMBL3751191 | 0.72 | ADORA2A (1.00) | ADORA2AADORA2BADORA1 | |
| SCHEMBL3660960 | 0.72 | ADORA2A (0.56) | CD38ADORA2AADORA2BADORA1ADORA3 | |
| SCHEMBL31266691 | 0.71 | CD38 (0.61) | CD38 | |
| SCHEMBL31266703 | 0.71 | CD38 (0.61) | CD38 | |
| SCHEMBL29495184 | 0.71 | CD38 (0.56) | CD38ADORA2AADORA2BADORA1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021021986-A1 | HETEROBICYCLIC AMIDES AS INHIBITORS OF CD38 | RIBON THERAPEUTICS, INC. (US) | 2021-02-04 | — | — | WO | disclosed |