Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9687387 | 0.99 | ACHE (0.50) | ACHEKMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL9685361 | 0.99 | ACHE (0.50) | ACHEKMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL9686312 | 0.99 | ACHE (0.50) | ACHEKMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL9693236 | 0.99 | ACHE (0.50) | ACHEKMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL9693691 | 0.97 | ACHE (0.49) | ACHEKMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL10564966 | 0.86 | KMT2A (0.45) | KMT2AKDM4EMEN1ALDH1A1GAA | |
| SCHEMBL9693650 | 0.85 | KMT2A (0.44) | KMT2AKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL9693220 | 0.85 | KMT2A (0.45) | ACHEKMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL9693887 | 0.85 | KMT2A (0.42) | ACHEKMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL7912951 | 0.84 | ACHE (0.49) | ACHEKMT2AKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110195950-A1 | Organic Compounds | NOVARTIS AG | 2011-08-11 | — | — | US | disclosed |
| EP-2188284-A2 | TRICYCLIC HETEROCYCLIC COMPOUNDS AS GABA A MODULATORS | Novartis Ag (CH) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009021957-A2 | TRICYCLIC HETEROCYCLIC COMPOUNDS AS GABA A MODULATORS | NOVARTIS AG (CH) | 2009-02-19 | — | — | WO | disclosed |
| EP-0168350-B1 | Certain ring-fused pyrazolo [3,4-d]-pyridin-3-one derivatives | CIBA-GEIGY AG (CH) | 1992-05-06 | — | — | EP | disclosed |
| US-4814450-A | CENTRAL NERVOUS SYSTEM DISORDERS | CIBA-GEIGY CORPORATION (US) | 1989-03-21 | — | — | US | disclosed |
| US-4740512-A | Treating anxiety with certain ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives | CIBA-GEIGY CORPORATION (US) | 1988-04-26 | — | — | US | disclosed |
| US-4647566-A | Certain ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives in treating anxiety | CIBA-GEIGY CORPORATION (US) | 1987-03-03 | — | — | US | disclosed |
| US-4602014-A | NERVOUS SYSTEM DISORDERS | CIBA-GEIGY CORPORATION (US) | 1986-07-22 | — | — | US | disclosed |
| EP-0168350-A2 | Certain ring-fused pyrazolo [3,4-d]-pyridin-3-one derivatives | CIBA-GEIGY AG (CH) | 1986-01-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110195950-A1 | Organic Compounds | NR3C2, NR4A1, NR4A2 | ACHE 3680/4885KMT2A 2375/4885KDM4E 3319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.