Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SETD2 | Q9BYW2 | 2/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | PHGDH | O43175 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12829317 | 0.85 | PIK3CD (0.43) | HRH3POLBCYP1A2TDP1KDM4E | |
| SCHEMBL4550241 | 0.81 | POLB (0.50) | HRH3POLBHSD17B10CYP1A2TDP1 | |
| SCHEMBL16809205 | 0.80 | MEN1 (0.43) | HRH3POLBHSD17B10CYP1A2TDP1 | |
| SCHEMBL20355941 | 0.80 | MEN1 (0.43) | HRH3POLBHSD17B10CYP1A2TDP1 | |
| SCHEMBL24192451 | 0.79 | USP2 (0.50) | SETD2NSD2CYP2C8DRD2HTR1B | |
| SCHEMBL21740356 | 0.78 | SETD2 (0.39) | SETD2NSD2CYP2C8DRD2HTR1B | |
| SCHEMBL13088446 | 0.77 | POLB (0.55) | HRH3POLBHSD17B10CYP1A2TDP1 | |
| SCHEMBL13627077 | 0.76 | HRH3 (0.48) | HRH3POLBHSD17B10CYP1A2TDP1 | |
| SCHEMBL13088457 | 0.76 | POLB (0.58) | HRH3POLBHSD17B10SIGMAR1PHGDH | |
| SCHEMBL13453747 | 0.76 | POLB (0.58) | HRH3POLBHSD17B10SIGMAR1PHGDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021195481-A1 | SMALL MOLECULE STAT PROTEIN DEGRADERS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2021-09-30 | — | — | WO | disclosed |
| WO-2021018194-A1 | HETEROCYCLIC COMPOUNDS AS BCR-ABL INHIBITORS | ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) | 2021-02-04 | — | — | WO | disclosed |