Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 15/20 | 0.59 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.54 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.54 |
| ▸ | IRAK3 | Q9Y616 | 2/20 | 0.54 |
| ▸ | AR | P10275 | 4/20 | 0.51 |
| ▸ | BTK | Q06187 | 3/20 | 0.50 |
| ▸ | CCNC | P24863 | 1/20 | 0.50 |
| ▸ | CDK8 | P49336 | 1/20 | 0.50 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.50 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.50 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.50 |
| ▸ | CDK9 | P50750 | 1/20 | 0.48 |
| ▸ | ITK | Q08881 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | HPGDS | O60760 | 1/20 | 0.45 |
| ▸ | RAF1 | P04049 | 2/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22940923 | 0.94 | CRBN (0.67) | CRBNIRAK1IRAK4IRAK3BTK | |
| SCHEMBL22941210 | 0.90 | CRBN (0.60) | CRBNIRAK1IRAK4IRAK3AR | |
| SCHEMBL24142015 | 0.86 | CRBN (0.58) | CRBNIRAK1IRAK4IRAK3AR | |
| SCHEMBL26814219 | 0.86 | CRBN (0.62) | CRBNIRAK1IRAK4IRAK3BTK | |
| SCHEMBL30938263 | 0.86 | CRBN (0.62) | CRBNIRAK1IRAK4IRAK3BTK | |
| SCHEMBL20046436 | 0.85 | CRBN (0.74) | CRBNARBTKCDK9DDB1 | |
| SCHEMBL30160860 | 0.85 | CRBN (0.74) | CRBNARBTKCDK9DDB1 | |
| SCHEMBL27176460 | 0.85 | CRBN (0.65) | CRBNIRAK1IRAK4IRAK3AR | |
| SCHEMBL27176462 | 0.85 | CRBN (0.65) | CRBNIRAK1IRAK4IRAK3AR | |
| SCHEMBL25504412 | 0.85 | CRBN (0.65) | CRBNIRAK1IRAK4IRAK3AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021018018-A1 | DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INIDBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2021-02-04 | — | — | WO | disclosed |