Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.64 |
| ▸ | MEN1 | O00255 | 4/20 | 0.64 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | EBP | Q15125 | 1/20 | 0.43 |
| ▸ | DHCR7 | Q9UBM7 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL81591 | 0.93 | L3MBTL3 (0.57) | KMT2AMEN1L3MBTL3L3MBTL1GRIN2B | |
| SCHEMBL18550791 | 0.90 | KMT2A (0.54) | KMT2AMEN1L3MBTL3L3MBTL1GRIN2B | |
| SCHEMBL26706269 | 0.90 | KMT2A (0.54) | KMT2AMEN1L3MBTL3L3MBTL1GRIN2B | |
| SCHEMBL82890 | 0.86 | L3MBTL3 (0.59) | KMT2AMEN1L3MBTL3L3MBTL1GRIN2B | |
| SCHEMBL18296369 | 0.86 | L3MBTL3 (0.58) | KMT2AMEN1L3MBTL3L3MBTL1GRIN2B | |
| SCHEMBL82007 | 0.86 | L3MBTL3 (0.58) | KMT2AMEN1L3MBTL3L3MBTL1GRIN2B | |
| SCHEMBL22848098 | 0.85 | KMT2A (0.66) | KMT2AMEN1L3MBTL3L3MBTL1GRIN2B | |
| SCHEMBL22175018 | 0.85 | KMT2A (0.62) | KMT2AMEN1L3MBTL3L3MBTL1 | |
| SCHEMBL15764103 | 0.84 | L3MBTL3 (0.56) | KMT2AMEN1L3MBTL3L3MBTL1GRIN2B | |
| SCHEMBL15764139 | 0.84 | L3MBTL3 (0.56) | KMT2AMEN1L3MBTL3L3MBTL1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021180103-A1 | DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2021-09-16 | — | — | WO | disclosed |
| WO-2021018018-A1 | DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INIDBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2021-02-04 | — | — | WO | disclosed |