Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP1LC3B | Q9GZQ8 | 3/20 | 0.40 |
| ▸ | TNF | P01375 | 2/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | IL1B | P01584 | 1/20 | 0.37 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.37 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | BTK | Q06187 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22941146 | 1.00 | MAP1LC3B (0.40) | MAP1LC3BTNFDDB1CRBNBRD4 | |
| SCHEMBL22940207 | 0.90 | MAP1LC3B (0.40) | MAP1LC3BTNFDDB1CRBNBRD4 | |
| SCHEMBL22941341 | 0.90 | MAP1LC3B (0.40) | MAP1LC3BTNFDDB1CRBNBRD4 | |
| SCHEMBL22940348 | 0.78 | BTK (0.60) | EGFRBTK | |
| SCHEMBL22940346 | 0.78 | BTK (0.60) | EGFRBTK | |
| SCHEMBL12072673 | 0.71 | CRBN (0.56) | MAP1LC3BTNFDDB1CRBNBRD4 | |
| SCHEMBL22940895 | 0.71 | CRBN (0.49) | MAP1LC3BTNFDDB1CRBNBRD4 | |
| SCHEMBL22941130 | 0.71 | CRBN (0.53) | MAP1LC3BTNFDDB1CRBNBRD4 | |
| Hydrochloric Acid SCHEMBL19359338 | 0.71 | CRBN (0.55) | MAP1LC3BTNFDDB1CRBNBRD4 | |
| SCHEMBL25834806 | 0.70 | CRBN (0.54) | MAP1LC3BTNFDDB1CRBNBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021018018-A1 | DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INIDBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2021-02-04 | — | — | WO | disclosed |