Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 18/20 | 0.63 |
| ▸ | DDB1 | Q16531 | 11/20 | 0.48 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.47 |
| ▸ | HPGDS | O60760 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.44 |
| ▸ | IRAK3 | Q9Y616 | 2/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | CCNC | P24863 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.43 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.43 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22940923 | 0.87 | CRBN (0.67) | CRBNDDB1HPGDSALDH1A1CHRM2 | |
| SCHEMBL22941210 | 0.83 | CRBN (0.60) | CRBNDDB1HPGDSIRAK1IRAK4 | |
| SCHEMBL22940303 | 0.83 | CRBN (0.60) | CRBNDDB1HPGDSALDH1A1IRAK1 | |
| SCHEMBL24926143 | 0.82 | CRBN (0.93) | CRBNDDB1ALDH1A1CHRM2OPRM1 | |
| SCHEMBL21946755 | 0.82 | CRBN (0.93) | CRBNDDB1ALDH1A1CHRM2OPRM1 | |
| SCHEMBL21946896 | 0.82 | CRBN (0.93) | CRBNDDB1ALDH1A1CHRM2OPRM1 | |
| SCHEMBL21946754 | 0.82 | CRBN (0.93) | CRBNDDB1ALDH1A1CHRM2OPRM1 | |
| SCHEMBL30066311 | 0.82 | CRBN (0.93) | CRBNDDB1ALDH1A1CHRM2OPRM1 | |
| SCHEMBL22940308 | 0.82 | CRBN (0.59) | CRBNDDB1HPGDSIRAK1IRAK4 | |
| SCHEMBL26815156 | 0.81 | CRBN (0.61) | CRBNDDB1HPGDSALDH1A1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021018018-A1 | DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INIDBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2021-02-04 | — | — | WO | disclosed |