Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | TDO2 | P48775 | 1/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.46 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | STS | P08842 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | GLS | O94925 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29577865 | 1.00 | BRD4 (0.53) | BRD4KDM4EPKMIDO1TDO2 | |
| SCHEMBL22943244 | 0.90 | BRD4 (0.51) | BRD4KDM4EPKMIDO1TDO2 | |
| SCHEMBL31226344 | 0.90 | BRD4 (0.51) | BRD4KDM4EPKMIDO1TDO2 | |
| SCHEMBL22944602 | 0.88 | BRD4 (0.50) | BRD4KDM4EPKMIDO1TDO2 | |
| SCHEMBL29579110 | 0.88 | BRD4 (0.50) | BRD4KDM4EPKMIDO1TDO2 | |
| SCHEMBL22944616 | 0.88 | BRD4 (0.51) | BRD4KDM4EPKMIDO1TDO2 | |
| SCHEMBL29578270 | 0.88 | BRD4 (0.51) | BRD4KDM4EPKMIDO1TDO2 | |
| SCHEMBL29578727 | 0.88 | JAK2 (0.50) | BRD4KDM4EPKMIDO1TDO2 | |
| SCHEMBL22944540 | 0.88 | JAK2 (0.50) | BRD4KDM4EPKMIDO1TDO2 | |
| SCHEMBL22944575 | 0.87 | BRD4 (0.49) | BRD4KDM4EPKMIDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114728949-A | Heterocyclic compounds as kinase inhibitors and uses thereof | 整体生物科学私人有限公司 | 2022-07-08 | — | — | CN | disclosed |
| WO-2021019514-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITOR AND USES THEREOF | INTEGRAL BIOSCIENCES PVT. LTD. (IN) | 2021-02-04 | — | — | WO | disclosed |