Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 16/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 14/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 13/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7895926 | 0.81 | ACHE (0.51) | — | |
| SCHEMBL12850618 | 0.77 | HDAC1 (0.79) | HDAC6HDAC1HDAC8HDAC2HDAC11 | |
| SCHEMBL7897153 | 0.77 | ACHE (0.47) | — | |
| SCHEMBL22944297 | 0.74 | HDAC6 (0.51) | HDAC6HDAC1HDAC8HDAC2HDAC11 | |
| SCHEMBL17078888 | 0.74 | HDAC6 (0.61) | HDAC6HDAC1HDAC8HDAC2HDAC11 | |
| SCHEMBL20432683 | 0.74 | HDAC6 (0.61) | HDAC6HDAC1HDAC8HDAC2HDAC11 | |
| SCHEMBL12938881 | 0.73 | HDAC6 (0.68) | HDAC6HDAC1HDAC8HDAC2HDAC11 | |
| SCHEMBL9937700 | 0.73 | NR4A2 (0.54) | — | |
| SCHEMBL30929656 | 0.73 | HDAC6 (0.69) | HDAC6HDAC1HDAC8HDAC11HDAC3 | |
| SCHEMBL28623180 | 0.73 | HDAC6 (0.69) | HDAC6HDAC1HDAC8HDAC11HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021021979-A2 | HDAC6 INHIBITORS AND USES THEREOF | EIKONIZO THERAPAPEUTICS, INC. (US) | 2021-02-04 | — | — | WO | disclosed |