Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG | P00747 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | UGT2B7 | P16662 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | BRD2 | P25440 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | OGA | O60502 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12807236 | 0.83 | HDAC8 (0.36) | MEN1KMT2AHDAC8ALDH1A1CYP3A4 | |
| SCHEMBL16876488 | 0.79 | HDAC8 (0.33) | HDAC8CYP3A4CYP2C19 | |
| SCHEMBL19846691 | 0.77 | UHRF1 (0.48) | PLGPLAUUGT2B7MEN1KMT2A | |
| SCHEMBL17198732 | 0.77 | UHRF1 (0.48) | PLGPLAUUGT2B7MEN1KMT2A | |
| SCHEMBL15277731 | 0.75 | PLG (0.41) | PLGPLAUUGT2B7MEN1KMT2A | |
| SCHEMBL514592 | 0.75 | NOS3 (0.48) | PLGPLAUUGT2B7MEN1KMT2A | |
| SCHEMBL21200276 | 0.75 | PLG (0.41) | PLGPLAUUGT2B7MEN1KMT2A | |
| SCHEMBL2040052 | 0.75 | RECQL (0.44) | PLGPLAUUGT2B7MEN1KMT2A | |
| SCHEMBL4330263 | 0.75 | RECQL (0.44) | PLGPLAUUGT2B7MEN1KMT2A | |
| SCHEMBL568609 | 0.75 | PLG (0.41) | PLGPLAUUGT2B7MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021021761-A1 | UREA, AMIDE, AND SUBSTITUTED HETEROARYL COMPOUNDS FOR CBL-B INHIBITION | NURIX THERAPEUTICS, INC. (US) | 2021-02-04 | — | — | WO | disclosed |