Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.64 |
| ▸ | BTK | Q06187 | 2/20 | 0.59 |
| ▸ | INSR | P06213 | 7/20 | 0.53 |
| ▸ | IGF1R | P08069 | 7/20 | 0.53 |
| ▸ | ALK | Q9UM73 | 7/20 | 0.53 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | STK10 | O94804 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | SLC34A2 | O95436 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | CD74 | P04233 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | FES | P07332 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22950925 | 1.00 | EGFR (0.64) | EGFRBTKINSRIGF1RALK | |
| SCHEMBL22950900 | 0.92 | EGFR (0.73) | EGFRBTKINSRIGF1RALK | |
| SCHEMBL22950965 | 0.90 | EGFR (0.62) | EGFRBTKINSRIGF1RALK | |
| SCHEMBL22942153 | 0.89 | EGFR (0.59) | EGFRBTKINSRIGF1RALK | |
| SCHEMBL22950967 | 0.88 | EGFR (0.59) | EGFRBTKCHEK1AURKAJAK2 | |
| SCHEMBL28775789 | 0.86 | EGFR (0.67) | EGFRBTKINSRIGF1RALK | |
| SCHEMBL22950973 | 0.86 | EGFR (0.79) | EGFRBTKINSRIGF1RALK | |
| SCHEMBL28529517 | 0.85 | EGFR (0.59) | EGFR | |
| SCHEMBL22950986 | 0.84 | EGFR (0.61) | EGFRBTKCHEK1AURKAJAK2 | |
| SCHEMBL29558563 | 0.84 | EGFR (0.61) | EGFRBTKCHEK1AURKAJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114430739-A | EGFR inhibitor, composition and preparation method thereof | 贝达药业股份有限公司 | 2022-05-03 | — | — | CN | disclosed |
| WO-2021018009-A1 | EGFR INHIBITOR, COMPOSITION, AND PREPARATION METHOD THEREFOR | 贝达药业股份有限公司 | 2021-02-04 | — | — | WO | disclosed |