Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.59 |
| ▸ | INSR | P06213 | 7/20 | 0.55 |
| ▸ | IGF1R | P08069 | 7/20 | 0.55 |
| ▸ | ALK | Q9UM73 | 7/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | STK10 | O94804 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | SLC34A2 | O95436 | 1/20 | 0.49 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | CD74 | P04233 | 1/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | FES | P07332 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | YES1 | P07947 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22942225 | 0.92 | EGFR (0.67) | EGFRINSRIGF1RALK | |
| SCHEMBL29559850 | 0.91 | EGFR (0.66) | EGFRINSRIGF1RALK | |
| SCHEMBL22942870 | 0.91 | EGFR (0.66) | EGFRINSRIGF1RALK | |
| SCHEMBL22942158 | 0.89 | LRRK2 (0.50) | EGFRINSRIGF1RALKLRRK2 | |
| SCHEMBL22942144 | 0.89 | INSR (0.69) | EGFRINSRIGF1RALKCHEK1 | |
| SCHEMBL22950927 | 0.89 | EGFR (0.64) | EGFRINSRIGF1RALKCHEK1 | |
| SCHEMBL22950925 | 0.89 | EGFR (0.64) | EGFRINSRIGF1RALKCHEK1 | |
| SCHEMBL24940078 | 0.88 | EGFR (0.60) | EGFRINSRIGF1RALK | |
| SCHEMBL30105850 | 0.88 | EGFR (0.60) | EGFRINSRIGF1RALK | |
| SCHEMBL22942164 | 0.88 | EGFR (0.60) | EGFRINSRIGF1RALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021018003-A1 | EGFR INHIBITOR, COMPOSITION, AND PREPARATION METHOD THEREFOR | 贝达药业股份有限公司 | 2021-02-04 | — | — | WO | disclosed |