Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.54 |
| ▸ | THPO | P40225 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.53 |
| ▸ | DRD1 | P21728 | 8/20 | 0.43 |
| ▸ | DRD2 | P14416 | 4/20 | 0.43 |
| ▸ | QDPR | P09417 | 1/20 | 0.38 |
| ▸ | DRD5 | P21918 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29868844 | 1.00 | PARP1 (0.61) | PARP1MAPK1CYP3A4NFKB1THPO | |
| SCHEMBL29626879 | 0.80 | MAPK1 (0.53) | PARP1MAPK1CYP3A4NFKB1THPO | |
| SCHEMBL22953429 | 0.80 | MAPK1 (0.53) | PARP1MAPK1CYP3A4NFKB1THPO | |
| SCHEMBL22953401 | 0.78 | PDE4A (0.41) | PARP1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL14494799 | 0.77 | PARP1 (0.68) | PARP1MAPK1CYP3A4NFKB1THPO | |
| SCHEMBL11102977 | 0.77 | PARP1 (0.68) | PARP1MAPK1CYP3A4NFKB1THPO | |
| SCHEMBL11098185 | 0.76 | PARP1 (1.00) | PARP1MAPK1CYP3A4NFKB1THPO | |
| Bromide SCHEMBL11102755 | 0.75 | PARP1 (0.97) | PARP1MAPK1CYP3A4NFKB1THPO | |
| Bromide SCHEMBL11100449 | 0.74 | PARP1 (0.94) | PARP1MAPK1CYP3A4NFKB1THPO | |
| SCHEMBL11101946 | 0.74 | PARP1 (0.80) | PARP1MAPK1CYP3A4NFKB1THPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4616906-A2 | BENZO[A]PHENANTHRIDINE DERIVATIVES AS YAP/TAZ INHIBITORS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2025-09-17 | — | — | EP | disclosed |
| US-20220267277-A1 | DOPAMINE RECEPTOR D1 AGONISTS AND METHODS OF USE | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2022-08-25 | — | — | US | disclosed |
| EP-4003339-A2 | DOPAMINE RECEPTOR D1 AGONISTS AND METHODS OF USE | Sanford Burnham Prebys Medical Discovery Institute (US) | 2022-06-01 | — | — | EP | disclosed |
| WO-2021021953-A2 | DOPAMINE RECEPTOR D1 AGONISTS AND METHODS OF USE | Sanford Burnham Prebys Medical Discovery Institute (US) | 2021-02-04 | — | — | WO | disclosed |
| WO-2021021953-A2 | DOPAMINE RECEPTOR D1 AGONISTS AND METHODS OF USE | Sanford Burnham Prebys Medical Discovery Institute (US) | 2021-02-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220267277-A1 | DOPAMINE RECEPTOR D1 AGONISTS AND METHODS OF USE | PRLHR, YAP1, MST1R | PARP1 2612/4885MAPK1 1277/4885CYP3A4 4707/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.