Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.62 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.50 |
| ▸ | PDE4A | P27815 | 8/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22954488 | 0.82 | OPRM1 (0.56) | OPRM1OPRL1PDE4BPDE4APDE4C | |
| SCHEMBL4872137 | 0.81 | OPRM1 (0.70) | OPRM1OPRL1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL8355555 | 0.80 | OPRM1 (0.68) | OPRM1OPRL1SIGMAR1 | |
| SCHEMBL3908960 | 0.79 | OPRM1 (0.71) | OPRM1OPRL1 | |
| SCHEMBL1267136 | 0.79 | OPRM1 (0.63) | OPRM1OPRL1SIGMAR1 | |
| SCHEMBL476404 | 0.78 | OPRM1 (1.00) | OPRM1OPRL1SIGMAR1 | |
| SCHEMBL13543973 | 0.77 | OPRL1 (0.79) | OPRM1OPRL1SIGMAR1 | |
| SCHEMBL21989255 | 0.77 | OPRM1 (0.57) | OPRM1OPRL1SIGMAR1 | |
| SCHEMBL8350406 | 0.77 | OPRM1 (0.81) | OPRM1OPRL1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL2473959 | 0.76 | OPRM1 (0.97) | OPRM1OPRL1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021018118-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 PROTEINS | JANSSEN PHARMACEUTICA NV (BE) | 2021-02-04 | — | — | WO | disclosed |