Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 10/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALPG | P10696 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8789817 | 0.93 | SMN1; SMN2 (0.51) | KMT2ASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL6377931 | 0.87 | KMT2A (0.57) | KMT2ASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL1697621 | 0.87 | MAPT (0.67) | KMT2ASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL657693 | 0.85 | CHEK1 (0.53) | KMT2ASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL17197367 | 0.85 | SMN1; SMN2 (0.52) | KMT2ASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL2964413 | 0.85 | KMT2A (0.52) | KMT2ASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL2976365 | 0.83 | MAPT (0.50) | KMT2ASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL224201 | 0.83 | KMT2A (0.50) | KMT2ASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL1961769 | 0.83 | CHRNB2 (0.57) | KMT2ASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL17197371 | 0.82 | SMN1; SMN2 (0.49) | KMT2ASMN1; SMN2NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021018118-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 PROTEINS | JANSSEN PHARMACEUTICA NV (BE) | 2021-02-04 | — | — | WO | disclosed |