Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 18/20 | 0.77 |
| ▸ | BRD4 | O60885 | 3/20 | 0.63 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.63 |
| ▸ | PLK3 | Q9H4B4 | 4/20 | 0.52 |
| ▸ | PLK2 | Q9NYY3 | 4/20 | 0.52 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1560558 | 0.94 | PLK1 (0.87) | PLK1BRD4BRDTPLK3PLK2 | |
| SCHEMBL1560401 | 0.91 | PLK1 (0.76) | PLK1BRD4BRDTPLK3PLK2 | |
| SCHEMBL1560479 | 0.91 | PLK1 (0.75) | PLK1BRD4BRDTPLK3PLK2 | |
| SCHEMBL1559960 | 0.91 | PLK1 (0.73) | PLK1BRD4BRDTPLK3PLK2 | |
| SCHEMBL1559376 | 0.90 | PLK1 (0.74) | PLK1BRD4BRDTPLK3PLK2 | |
| SCHEMBL2299583 | 0.90 | PLK1 (0.74) | PLK1BRD4BRDTALK | |
| SCHEMBL1560553 | 0.87 | PLK1 (0.70) | PLK1BRD4BRDTPLK3PLK2 | |
| SCHEMBL1559906 | 0.87 | PLK1 (0.67) | PLK1BRD4BRDTPLK3PLK2 | |
| SCHEMBL3549236 | 0.87 | PLK1 (0.76) | PLK1BRD4BRDTPLK3PLK2 | |
| Tak-960 SCHEMBL30047124 | 0.87 | PLK1 (1.00) | PLK1BRD4BRDTPLK3PLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003785-B2 | Halo-substituted pyrimidodiazepines | TAKEDA PHARMACEUTICAL COMPANY LIMITED (US) | 2011-08-23 | — | — | US | disclosed |