Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 16/20 | 0.74 |
| ▸ | BRD4 | O60885 | 5/20 | 0.74 |
| ▸ | BRDT | Q58F21 | 4/20 | 0.74 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.57 |
| ▸ | RAD52 | P43351 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1559929 | 0.94 | PLK1 (0.84) | PLK1BRD4BRDTALKRAD52 | |
| SCHEMBL2299487 | 0.93 | PLK1 (0.74) | PLK1BRD4BRDTALKRAD52 | |
| SCHEMBL2299916 | 0.92 | PLK1 (0.88) | PLK1BRD4BRDTALKRAD52 | |
| SCHEMBL2299520 | 0.92 | PLK1 (0.73) | PLK1BRD4BRDTALKRAD52 | |
| SCHEMBL2297279 | 0.91 | PLK1 (0.87) | PLK1BRD4BRDTALKRAD52 | |
| SCHEMBL12386462 | 0.91 | PLK1 (0.73) | PLK1BRD4BRDTALKRAD52 | |
| SCHEMBL1560725 | 0.91 | PLK1 (0.71) | PLK1BRD4BRDTALKRAD52 | |
| SCHEMBL2298489 | 0.91 | PLK1 (0.79) | PLK1BRD4BRDTALKRAD52 | |
| SCHEMBL1560402 | 0.90 | PLK1 (0.72) | PLK1BRD4BRDTALKRAD52 | |
| SCHEMBL1559834 | 0.90 | PLK1 (0.72) | PLK1BRD4BRDTALKRAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003785-B2 | Halo-substituted pyrimidodiazepines | TAKEDA PHARMACEUTICAL COMPANY LIMITED (US) | 2011-08-23 | — | — | US | disclosed |