Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.54 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.49 |
| ▸ | IKBKB | O14920 | 1/20 | 0.49 |
| ▸ | USP28 | Q96RU2 | 2/20 | 0.48 |
| ▸ | USP25 | Q9UHP3 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 10/20 | 0.48 |
| ▸ | NPC1 | O15118 | 9/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.44 |
| ▸ | RELA | Q04206 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19212248 | 0.87 | ADORA2A (0.60) | ADORA2ALIMK1IKBKBUSP28USP25 | |
| SCHEMBL14955421 | 0.84 | ADORA2A (0.75) | ADORA2ALIMK1IKBKBUSP28USP25 | |
| SCHEMBL22957572 | 0.83 | KDM4E (0.57) | RAB9ANPC1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL30968438 | 0.78 | LIMK1 (0.51) | ADORA2ALIMK1IKBKBRAB9ANPC1 | |
| SCHEMBL19212039 | 0.78 | LIMK1 (0.77) | ADORA2ALIMK1IKBKBUSP28USP25 | |
| SCHEMBL8091104 | 0.78 | LIMK1 (0.51) | ADORA2ALIMK1IKBKBUSP28USP25 | |
| SCHEMBL20722660 | 0.78 | LIMK1 (0.51) | ADORA2ALIMK1IKBKBRAB9ANPC1 | |
| SCHEMBL29707312 | 0.78 | LIMK1 (0.77) | ADORA2ALIMK1IKBKBUSP28USP25 | |
| SCHEMBL25808577 | 0.76 | LIMK1 (0.52) | ADORA2ALIMK1IKBKBUSP28USP25 | |
| SCHEMBL20722419 | 0.75 | LIMK1 (0.51) | ADORA2ALIMK1IKBKBUSP28USP25 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10913753-B2 | Thienopyridine carboxamides as ubiquitin-specific protease inhibitors | VALO EARLY DISCOVERY, INC. (US) | 2021-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10913753-B2 | Thienopyridine carboxamides as ubiquitin-specific protease inhibitors | USP28, USP25, USP24 | ADORA2A 4060/4885LIMK1 4691/4885IKBKB 410/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.