Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15081065 | 1.00 | CRHBP (0.46) | CRHBPCRHR2THRBLMNATDP1 | |
| SCHEMBL16945977 | 0.98 | CRHBP (0.43) | CRHBPCRHR2THRBLMNATDP1 | |
| SCHEMBL15499255 | 0.91 | CRHBP (0.37) | CRHBPCRHR2THRBLMNATDP1 | |
| SCHEMBL12513920 | 0.84 | CRHBP (0.44) | CRHBPCRHR2THRBLMNATDP1 | |
| SCHEMBL26745942 | 0.82 | CRHBP (0.37) | CRHBPCRHR2THRBLMNATDP1 | |
| SCHEMBL13197466 | 0.82 | MEN1 (0.39) | HCN4MAPT | |
| SCHEMBL28151536 | 0.82 | MEN1 (0.39) | HCN4MAPT | |
| SCHEMBL10129209 | 0.82 | MEN1 (0.39) | HCN4MAPT | |
| SCHEMBL23980022 | 0.80 | CRHBP (0.35) | CRHBPCRHR2THRBLMNATDP1 | |
| SCHEMBL24357949 | 0.80 | MEN1 (0.37) | HCN4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021028362-A1 | SHP2 INHIBITORS | IRBM S.P.A. (IT) | 2021-02-18 | — | — | WO | disclosed |
| EP-3772513-A1 | SHP2 INHIBITORS | C.N.C.C.S. S.c.a.r.l. Collezione Nazionale Dei Composti Chimici e Centro Screening (IT) | 2021-02-10 | — | — | EP | disclosed |