SCHEMBL22958645

SCHEMBL22958645

c1cc2c3c(c1)Oc1cc(-c4ccccc4-c4ccc(-c5ccc6ccccc6c5)cc4)ccc1N3c1ccc(-c3ccccc3-c3ccc(-c4ccc5ccccc5c4)cc3)cc1O2

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSTP1 P09211 1/20 0.38
ESR1 P03372 1/20 0.38
ESR2 Q92731 1/20 0.38
LPL P06858 1/20 0.37
LIPG Q9Y5X9 1/20 0.37
HSD17B1 P14061 1/20 0.36
HSD17B2 P37059 1/20 0.36
HDAC4 P56524 1/20 0.36
HDAC2 Q92769 1/20 0.36
HDAC8 Q9BY41 1/20 0.36
MAPT P10636 2/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
KDM4E B2RXH2 2/20 0.35
NPC1 O15118 1/20 0.35
ALDH1A1 P00352 1/20 0.35
POLB P06746 1/20 0.35
RAB9A P51151 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
MAPK1 P28482 1/20 0.34
ATM Q13315 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22958745 0.97 MAPT (0.39) GSTP1ESR1ESR2LPLLIPG
SCHEMBL22958765 0.94 MAPT (0.39) GSTP1ESR1ESR2LPLLIPG
SCHEMBL22958664 0.92 ESR1 (0.36) GSTP1ESR1ESR2LPLLIPG
SCHEMBL22958764 0.91 GSTP1 (0.37) GSTP1ESR1ESR2LPLLIPG
SCHEMBL22958776 0.90 SMN1; SMN2 (0.38) GSTP1ESR1ESR2LPLLIPG
SCHEMBL22958662 0.89 ESR1 (0.38) GSTP1ESR1ESR2LPLLIPG
SCHEMBL22958650 0.89 ATM (0.33) MAPTSMN1; SMN2KDM4ENPC1ALDH1A1
SCHEMBL22958651 0.87 ATM (0.34) MAPTSMN1; SMN2KDM4ENPC1ALDH1A1
SCHEMBL22958647 0.87 PDE6D (0.33) MAPTSMN1; SMN2KDM4ENPC1ALDH1A1
SCHEMBL22958731 0.87 PDE6D (0.33) MAPTSMN1; SMN2KDM4ENPC1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210043852-A1 HETEROCYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME SAMSUNG DISPLAY CO., LTD. (KR) 2021-02-11 US disclosed