Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 4/20 | 0.61 |
| ▸ | CRBN | Q96SW2 | 9/20 | 0.61 |
| ▸ | DDB1 | Q16531 | 7/20 | 0.61 |
| ▸ | CA2 | P00918 | 2/20 | 0.58 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.58 |
| ▸ | IDO1 | P14902 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 3/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.52 |
| ▸ | GRAMD1A | Q96CP6 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22959805 | 1.00 | STAT3 (0.61) | STAT3CRBNDDB1CA2DYRK2 | |
| SCHEMBL22959653 | 0.99 | STAT3 (0.62) | STAT3CRBNDDB1CA2DYRK2 | |
| SCHEMBL22959687 | 0.98 | CRBN (0.63) | STAT3CRBNDDB1CA2DYRK2 | |
| SCHEMBL29880821 | 0.92 | CRBN (0.71) | STAT3CRBNDDB1CA2DYRK2 | |
| SCHEMBL23884279 | 0.91 | CRBN (0.61) | STAT3CRBNDDB1CA2DYRK2 | |
| SCHEMBL23568580 | 0.90 | CRBN (0.68) | STAT3CRBNDDB1CA2 | |
| SCHEMBL23905164 | 0.90 | CRBN (0.59) | STAT3CRBNDDB1CA2DYRK2 | |
| SCHEMBL26814949 | 0.89 | CRBN (0.56) | STAT3CRBNDDB1CA2DYRK2 | |
| SCHEMBL22892868 | 0.88 | CRBN (0.66) | STAT3CRBNDDB1CA2DYRK2 | |
| SCHEMBL21259428 | 0.88 | CRBN (0.66) | STAT3CRBNDDB1CA2DYRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11771697-B2 | Small molecule degraders of polybromo-1 (PBRM1) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-10-03 | — | — | US | disclosed |
| US-20210038599-A1 | SMALL MOLECULE DEGRADERS OF POLYBROMO-1 (PBRM1) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11771697-B2 | Small molecule degraders of polybromo-1 (PBRM1) | PBRM1, SMARCC1, SMARCC2 | STAT3 1439/4885CRBN 65/4885DDB1 395/4885 |
| US-20210038599-A1 | SMALL MOLECULE DEGRADERS OF POLYBROMO-1 (PBRM1) | PBRM1, SMARCC1, SMARCC2 | STAT3 1439/4885CRBN 65/4885DDB1 395/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.