Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL2291719 | 0.99 | ALDH1A1 (0.39) | ALDH1A1TSHRTHRBHSD17B10GSK3A | |
| SCHEMBL2292195 | 0.98 | ALDH1A1 (0.41) | ALDH1A1TSHRTHRBHSD17B10GSK3A | |
| Bromide SCHEMBL2289747 | 0.90 | ALDH1A1 (0.36) | ALDH1A1SMN1; SMN2 | |
| Bromide SCHEMBL2291320 | 0.90 | ALDH1A1 (0.36) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL2293228 | 0.88 | ALDH1A1 (0.37) | ALDH1A1TSHRSMN1; SMN2 | |
| Bromide SCHEMBL2291109 | 0.87 | MEN1 (0.37) | ALDH1A1TSHRSMN1; SMN2 | |
| Bromide SCHEMBL2293289 | 0.87 | TSHR (0.31) | ALDH1A1TSHRSMN1; SMN2 | |
| Bromide SCHEMBL2760616 | 0.86 | ALDH1A1 (0.43) | ALDH1A1TSHRGSK3AGSK3BSMN1; SMN2 | |
| Bromide SCHEMBL2761202 | 0.86 | GSK3A (0.42) | ALDH1A1GSK3AGSK3B | |
| SCHEMBL2290250 | 0.85 | TSHR (0.32) | ALDH1A1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183220-B1 | BIODEGRADABLE SOLVENTS FOR THE CHEMICAL INDUSTRY | UNIV DUBLIN CITY (IE) | 2016-11-09 | — | — | EP | disclosed |
| US-20110201824-A1 | BIODEGRADABLE SOLVENTS FOR THE CHEMICAL INDUSTRY | DUBLIN CITY UNIVERSITY (IE) | 2011-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201824-A1 | BIODEGRADABLE SOLVENTS FOR THE CHEMICAL INDUSTRY | TIMM9, B2M, TIMM44 | ALDH1A1 1385/4885TSHR 2999/4885THRB 2236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.