Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.85 |
| ▸ | KDR | P35968 | 2/20 | 0.76 |
| ▸ | CIT | O14578 | 1/20 | 0.76 |
| ▸ | GAK | O14976 | 1/20 | 0.76 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.76 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.76 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.76 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.76 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.76 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.76 |
| ▸ | STK17B | O94768 | 1/20 | 0.76 |
| ▸ | STK10 | O94804 | 1/20 | 0.76 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.76 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.76 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.76 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.76 |
| ▸ | ABL1 | P00519 | 1/20 | 0.76 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.76 |
| ▸ | LCK | P06239 | 1/20 | 0.76 |
| ▸ | LYN | P07948 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12012 | 0.92 | EGFR (1.00) | EGFRKDRCITGAKEPHB6 | |
| SCHEMBL17520338 | 0.92 | EGFR (1.00) | EGFRKDRCITGAKEPHB6 | |
| SCHEMBL11395 | 0.91 | EGFR (1.00) | EGFRKDRCITGAKEPHB6 | |
| SCHEMBL17520333 | 0.90 | EGFR (0.95) | EGFRKDRCITGAKEPHB6 | |
| SCHEMBL22338480 | 0.88 | EGFR (0.92) | EGFRKDRCITGAKEPHB6 | |
| SCHEMBL18445807 | 0.88 | EGFR (0.81) | EGFRKDRCITGAKEPHB6 | |
| SCHEMBL17520332 | 0.88 | EGFR (1.00) | EGFRKDRCITGAKEPHB6 | |
| SCHEMBL11132 | 0.88 | EGFR (1.00) | EGFRKDRCITGAKEPHB6 | |
| SCHEMBL15939085 | 0.88 | EGFR (0.79) | EGFRKDRCITGAKEPHB6 | |
| SCHEMBL15946893 | 0.88 | EGFR (0.79) | EGFRKDRCITGAKEPHB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021023233-A1 | EGFR PROTEIN DEGRADANT AND ANTI-TUMOR APPLICATION THEREOF | 上海科技大学 | 2021-02-11 | — | — | WO | disclosed |