SCHEMBL22964675

SCHEMBL22964675

C[C@@H]1CN(c2cccc(NC(=O)c3ccc(NS(=O)(=O)CCO)cc3N3CCC4(CC3)CC4)c2F)CCO1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ KIF18A Q8NI77 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29446019 1.00 KIF18A (1.00) KIF18A
SCHEMBL22964676 0.88 KIF18A (1.00) KIF18A
SCHEMBL29446022 0.88 KIF18A (1.00) KIF18A
SCHEMBL22964485 0.86 KIF18A (1.00) KIF18A
SCHEMBL29446033 0.86 KIF18A (1.00) KIF18A
SCHEMBL26152736 0.86 KIF18A (0.82) KIF18A
SCHEMBL22964681 0.85 KIF18A (1.00) KIF18A
SCHEMBL29446020 0.85 KIF18A (1.00) KIF18A
SCHEMBL24319140 0.84 KIF18A (1.00) KIF18A
SCHEMBL22152106 0.84 KIF18A (1.00) KIF18A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021026098-A1 KIF18A INHIBITORS AMGEN INC. (US) 2021-02-11 — — WO disclosed
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