⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2808914 | 0.75 | ALDH1A1 (0.52) | — | |
| SCHEMBL18226691 | 0.74 | — | — | |
| SCHEMBL10581620 | 0.70 | — | — | |
| SCHEMBL25216305 | 0.70 | ALDH1A1 (0.46) | — | |
| SCHEMBL12019112 | 0.70 | ALDH1A1 (0.65) | — | |
| SCHEMBL2049404 | 0.69 | ALDH1A1 (0.44) | — | |
| SCHEMBL2254659 | 0.69 | ALDH1A1 (0.49) | — | |
| SCHEMBL49811 | 0.67 | ALDH1A1 (0.55) | — | |
| SCHEMBL247292 | 0.67 | — | — | |
| SCHEMBL9642004 | 0.67 | ALDH1A1 (0.72) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12479824-B2 | Method for preparing ivosidenib and an intermediate thereof | SERVIER PHARMACEUTICALS LLC (US) | 2025-11-25 | — | — | US | claimed |
| CN-114555584-B | Ai Funi cloth (IVOSIDENIB) and process for producing intermediate thereof | 法国施维雅药厂 | 2024-07-05 | — | — | CN | claimed |
| EP-4010331-B1 | A METHOD FOR PREPARING IVOSIDENIB AND AN INTERMEDIATE THEREOF | SERVIER LAB (FR) | 2023-10-04 | — | — | EP | claimed |
| US-20230025411-A1 | A METHOD FOR PREPARING IVOSIDENIB AND AN INTERMEDIATE THEREOF | SERVIER PHARMACEUTICALS LLC | 2023-01-26 | — | — | US | claimed |
| EP-4010331-A1 | A METHOD FOR PREPARING IVOSIDENIB AND AN INTERMEDIATE THEREOF | Les Laboratoires Servier (FR) | 2022-06-15 | — | — | EP | claimed |
| CN-114555584-A | Process for the preparation of ivonib (IVOSIDENIB) and intermediates thereof | 法国施维雅药厂 | 2022-05-27 | — | — | CN | claimed |
| CN-118580235-A | Preparation method of lactam compound | 正大天晴药业集团股份有限公司 | 2024-09-03 | — | — | CN | disclosed |
| EP-4010331-B1 | A METHOD FOR PREPARING IVOSIDENIB AND AN INTERMEDIATE THEREOF | SERVIER LAB (FR) | 2023-10-04 | — | — | EP | disclosed |
| US-20230025411-A1 | A METHOD FOR PREPARING IVOSIDENIB AND AN INTERMEDIATE THEREOF | SERVIER PHARMACEUTICALS LLC | 2023-01-26 | — | — | US | disclosed |
| CN-111065630-B | Internal sulfonamide compound crystal | 正大天晴药业集团股份有限公司 | 2022-12-30 | — | — | CN | disclosed |
| CN-109071429-B | Prophyridine sulfonamide compounds and methods of use thereof | 正大天晴药业集团股份有限公司 | 2021-04-02 | — | — | CN | disclosed |
| WO-2021026436-A1 | A METHOD FOR PREPARING IVOSIDENIB AND AN INTERMEDIATE THEREOF | AGIOS PHARMACEUTICALS, INC. (US) | 2021-02-11 | — | — | WO | disclosed |
| CN-111065630-A | Internal sulfonamide compound crystal | 正大天晴药业集团股份有限公司 | 2020-04-24 | — | — | CN | disclosed |
| CN-106496090-B | Therapeutically active compounds and methods of use thereof | 安吉奥斯医药品有限公司 | 2020-04-21 | — | — | CN | disclosed |