⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL153237 | 0.76 | — | — | |
| Hydrochloric Acid SCHEMBL11770579 | 0.73 | — | — | |
| SCHEMBL1863884 | 0.72 | KDM7A (0.43) | — | |
| SCHEMBL2755808 | 0.71 | — | — | |
| Acetic Acid SCHEMBL27750264 | 0.71 | KDM7A (0.44) | — | |
| SCHEMBL1526296 | 0.69 | — | — | |
| Acetamide SCHEMBL6158507 | 0.69 | LMNA (0.47) | — | |
| SCHEMBL11231825 | 0.67 | — | — | |
| SCHEMBL9298097 | 0.67 | — | — | |
| Sulfuric Acid SCHEMBL27941815 | 0.67 | KDM7A (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11697648-B2 | Fused pyrimidine pyridinone compounds as JAK inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2023-07-11 | — | — | US | disclosed |
| CN-115433235-A | Organic phosphaphenanthrene derivative with hydroxyl structure and preparation method thereof | 中国科学院化学研究所 | 2022-12-06 | — | — | CN | disclosed |
| EP-4065578-A1 | FUSED PYRIMIDINE PYRIDINONE COMPOUNDS AS JAK INHIBITORS | Theravance Biopharma R&D IP, LLC (US) | 2022-10-05 | — | — | EP | disclosed |
| CN-114901659-A | Fused pyrimidinone compounds as JAK inhibitors | 施万生物制药研发IP有限责任公司 | 2022-08-12 | — | — | CN | disclosed |
| CN-114890619-A | Device and method for treating wastewater of dimethylaminocarbonyl chloride | 安徽广信农化股份有限公司 | 2022-08-12 | — | — | CN | disclosed |
| US-20210188844-A1 | FUSED PYRIMIDINE PYRIDINONE COMPOUNDS AS JAK INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2021-06-24 | — | — | US | disclosed |
| WO-2021108803-A1 | FUSED PYRIMIDINE PYRIDINONE COMPOUNDS AS JAK INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2021-06-03 | — | — | WO | disclosed |
| US-9340529-B2 | Triazolones as fatty acid synthase inhibitors | GLAXOSMITHKLINE LLC (US) | 2016-05-17 | — | — | US | disclosed |
| US-20150051203-A1 | TRIAZOLE DERIVATIVES AS HSP90 INHIBITORS | SYNTA PHARMACEUTICALS CORP. | 2015-02-19 | — | — | US | disclosed |
| EP-2831061-A1 | TRIAZOLE DERIVATIVES AS HSP90 INHIBITORS | Synta Pharmaceuticals Corp. (US) | 2015-02-04 | — | — | EP | disclosed |
| US-5648372-A | TRIAZOLES | EISAI CO., LTD. (JP) | 1997-07-15 | — | — | US | disclosed |
| EP-0742196-A1 | CYCLOOCTADIENE DERIVATIVE | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1996-11-13 | — | — | EP | disclosed |
| EP-0667346-A2 | Azole antifungal agents, process for the preparation there of and intermediates | Eisai Co., Ltd. (JP) | 1995-08-16 | — | — | EP | disclosed |
| US-5346907-A | Cholecystokinin antagonists used in treatment or prevention of disorders of gastrointestinal, central nervous, appetite regulating or pain regulating systems | ABBOTT LABORATORIES (US) | 1994-09-13 | — | — | US | disclosed |
| EP-0319170-B1 | ACYL DERIVATIVES OF HYDROXY PYRIMIDINES | PFIZER INC. (US) | 1993-03-17 | — | — | EP | disclosed |
| US-4940712-A | Derivatives of hydroxyprimidines as leukotriene synthesis inhibitors | PFIZER INC. (US) | 1990-07-10 | — | — | US | disclosed |
| WO-1989005295-A1 | ACYL DERIVATIVES OF HYDROXYPYRIMIDINES | PFIZER INC. (US) | 1989-06-15 | — | — | WO | disclosed |
| EP-0319170-A2 | Acyl derivatives of hydroxy pyrimidines | PFIZER INC. (US) | 1989-06-07 | — | — | EP | disclosed |
| US-4252943-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1981-02-24 | — | — | US | disclosed |
| US-4217359-A | HYPOTENSIVE | E. R. SQUIBB & SONS, INC. (US) | 1980-08-12 | — | — | US | disclosed |