Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21360900 | 0.90 | PDGFRB (0.39) | PDE10APDGFRBPDGFRAGRM2ALDH1A1 | |
| SCHEMBL21338796 | 0.86 | PDGFRB (0.35) | PDE10APDGFRBPDGFRAGRM2ALDH1A1 | |
| SCHEMBL8404384 | 0.80 | CYP1A2 (0.54) | ALDH1A1CYP1A2KMT2ANPSR1KDM4E | |
| SCHEMBL26323741 | 0.74 | PDGFRB (0.45) | PDE10APDGFRBPDGFRAMAOBHSD17B10 | |
| SCHEMBL21622433 | 0.74 | PDE10A (0.50) | PDE10AALDH1A1CYP1A2KMT2ANPSR1 | |
| SCHEMBL553758 | 0.72 | PDE10A (0.49) | PDE10AALDH1A1CYP1A2KMT2ANPSR1 | |
| SCHEMBL15724737 | 0.72 | KMT2A (0.51) | PDE10AALDH1A1CYP1A2KMT2ANPSR1 | |
| SCHEMBL20155161 | 0.72 | CYP1A2 (0.41) | PDE10AGRM2ALDH1A1CYP1A2KMT2A | |
| SCHEMBL22594086 | 0.71 | CYP1A2 (0.39) | PDE10AALDH1A1CYP1A2KMT2ANPSR1 | |
| SCHEMBL22475741 | 0.70 | PDE10A (0.47) | PDE10AALDH1A1CYP1A2KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11667667-B2 | Steroid derivative FXR agonist | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2023-06-06 | — | — | US | disclosed |
| US-20210040140-A1 | Steroid Derivative FXR Agonist | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2021-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11667667-B2 | Steroid derivative FXR agonist | NR1H4, SLC10A1, FXR1 | PDE10A 1175/4885PDGFRB 2835/4885PDGFRA 2970/4885 |
| US-20210040140-A1 | Steroid Derivative FXR Agonist | NR1H4, SLC10A1, FXR1 | PDE10A 1175/4885PDGFRB 2835/4885PDGFRA 2970/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.