Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | IKBKE | Q14164 | 3/20 | 0.48 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.48 |
| ▸ | CCND3 | P30281 | 2/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.46 |
| ▸ | CCNK | O75909 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | LYN | P07948 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 2/20 | 0.44 |
| ▸ | CCND1 | P24385 | 2/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 3/20 | 0.43 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30206206 | 0.86 | PLK4 (0.59) | NPC1RAB9APLK4JAK2SYK | |
| SCHEMBL5256909 | 0.82 | KARS1 (0.47) | NPC1RAB9ACCND3CDK6CCNK | |
| SCHEMBL22970759 | 0.80 | CDK4 (0.47) | NPC1RAB9AIKBKETBK1POLB | |
| SCHEMBL22970904 | 0.80 | CDK4 (0.49) | NPC1RAB9AIKBKETBK1CDK6 | |
| SCHEMBL22970972 | 0.78 | NPC1 (0.43) | NPC1RAB9APLK4IGF1RMAPK10 | |
| SCHEMBL3137946 | 0.77 | CYP1A1 (0.48) | NPC1RAB9ACCND3CDK6CCNK | |
| SCHEMBL16245666 | 0.77 | CHRNB4 (0.50) | NPC1RAB9ACCND3CDK6CCNK | |
| Hydrochloric Acid SCHEMBL3134638 | 0.76 | CYP1A1 (0.47) | NPC1RAB9ACCND3CDK6CCNK | |
| SCHEMBL12569861 | 0.76 | POLB (0.51) | NPC1RAB9ATBK1CCND3CDK6 | |
| SCHEMBL12952691 | 0.76 | POLB (0.51) | NPC1RAB9ACCND3CDK6CCNK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210038607-A1 | OXADIAZOLYLTHIOPHENE DERIVATIVES USEFUL AS HISTONE DEACETYLASE INHIBITORS | KARUS THERAPEUTICS LIMITED (GB) | 2021-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210038607-A1 | OXADIAZOLYLTHIOPHENE DERIVATIVES USEFUL AS HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC5, HDAC3 | NPC1 2871/4885RAB9A 3697/4885IKBKE 1670/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.