Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 18/20 | 0.87 |
| ▸ | BRD4 | O60885 | 5/20 | 0.87 |
| ▸ | BRDT | Q58F21 | 5/20 | 0.87 |
| ▸ | RAD52 | P43351 | 1/20 | 0.68 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2299916 | 0.99 | PLK1 (0.88) | PLK1BRD4BRDTRAD52ALK | |
| SCHEMBL12330693 | 0.94 | PLK1 (0.92) | PLK1BRD4BRDTRAD52ALK | |
| SCHEMBL1559612 | 0.94 | PLK1 (0.92) | PLK1BRD4BRDTRAD52ALK | |
| SCHEMBL2298489 | 0.94 | PLK1 (0.79) | PLK1BRD4BRDTRAD52ALK | |
| SCHEMBL1675705 | 0.94 | PLK1 (0.88) | PLK1BRD4BRDTRAD52ALK | |
| SCHEMBL1560010 | 0.94 | PLK1 (0.99) | PLK1BRD4BRDTRAD52ALK | |
| SCHEMBL1675854 | 0.94 | PLK1 (0.90) | PLK1BRD4BRDTRAD52ALK | |
| SCHEMBL2299733 | 0.93 | PLK1 (0.82) | PLK1BRD4BRDTRAD52 | |
| SCHEMBL1559146 | 0.93 | PLK1 (1.00) | PLK1BRD4BRDTRAD52ALK | |
| SCHEMBL29377237 | 0.93 | PLK1 (1.00) | PLK1BRD4BRDTRAD52ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003785-B2 | Halo-substituted pyrimidodiazepines | TAKEDA PHARMACEUTICAL COMPANY LIMITED (US) | 2011-08-23 | — | — | US | disclosed |