Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL503583 | 1.00 | ALDH1A1 (0.58) | ALDH1A1GRM4MAPTNPSR1KDM4E | |
| Hydrochloric Acid SCHEMBL3813837 | 0.99 | ALDH1A1 (0.60) | ALDH1A1GRM4MAPTNPSR1KDM4E | |
| Hydrochloric Acid SCHEMBL2787874 | 0.99 | ALDH1A1 (0.60) | ALDH1A1GRM4MAPTNPSR1KDM4E | |
| SCHEMBL1376225 | 0.89 | ALDH1A1 (0.48) | ALDH1A1GRM4MAPTNPSR1KDM4E | |
| SCHEMBL27623048 | 0.89 | ALDH1A1 (0.48) | ALDH1A1GRM4MAPTNPSR1KDM4E | |
| SCHEMBL9450673 | 0.89 | GRM4 (0.50) | ALDH1A1GRM4MAPTNPSR1KDM4E | |
| SCHEMBL22557986 | 0.88 | ALDH1A1 (0.73) | ALDH1A1GRM4MAPTNPSR1KDM4E | |
| SCHEMBL11397934 | 0.88 | ALDH1A1 (0.73) | ALDH1A1GRM4MAPTNPSR1KDM4E | |
| SCHEMBL6935540 | 0.88 | ALDH1A1 (0.73) | ALDH1A1GRM4MAPTNPSR1KDM4E | |
| Hydrochloric Acid SCHEMBL6935538 | 0.87 | ALDH1A1 (0.76) | ALDH1A1GRM4MAPTNPSR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109562116-A | Protona and protona derivative and promotor in cancer treatment | 迪美公司 | 2019-04-02 | — | — | CN | claimed |
| CN-106232105-A | Tyrosine derivative and comprise the compositions of tyrosine derivative | 迪美公司 | 2016-12-14 | — | — | CN | claimed |
| CN-105848652-A | Tyrosine hydroxylase inhibitors for the treatment of intestinal hyperpermeability | 史蒂文·霍夫曼 | 2016-08-10 | — | — | CN | claimed |
| CN-114945374-A | Pharmaceutical compositions and methods | 迪美公司 | 2022-08-26 | — | — | CN | disclosed |
| EP-3238707-B1 | COMPOSITIONS AND METHODS FOR TREATING INTESTINAL HYPERPERMEABILITY | HOFFMAN STEVE (US) | 2021-02-17 | — | — | EP | disclosed |
| CN-104220057-B | Pharmaceutical compositions and methods | 迪美公司 | 2017-11-03 | — | — | CN | disclosed |