Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2B6 | P20813 | 1/20 | 0.62 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12665881 | 0.98 | CYP2B6 (0.66) | CYP2B6HSD11B1HPGDALDH1A1CHEK1 | |
| SCHEMBL29173728 | 0.84 | ALDH1A1 (0.46) | CYP2B6HSD11B1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL18580610 | 0.82 | CYP2B6 (0.43) | CYP2B6HSD11B1HPGDALDH1A1 | |
| SCHEMBL578326 | 0.82 | ALDH1A1 (0.44) | CYP2B6HSD11B1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL31583791 | 0.81 | CYP2B6 (0.42) | CYP2B6HSD11B1HPGD | |
| SCHEMBL8354616 | 0.81 | CYP2B6 (0.64) | CYP2B6HSD11B1HPGDALDH1A1CHEK1 | |
| SCHEMBL5644958 | 0.79 | CYP2B6 (0.62) | CYP2B6CHEK1ACHESMN1; SMN2NPC1 | |
| SCHEMBL8354397 | 0.79 | CYP2B6 (0.68) | CYP2B6HPGDALDH1A1CHEK1ACHE | |
| SCHEMBL19011533 | 0.78 | CYP2B6 (0.96) | CYP2B6ACHESMN1; SMN2LMNASIGMAR1 | |
| SCHEMBL19690280 | 0.77 | CYP2B6 (0.59) | CYP2B6HPGDALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7999117-B2 | Substituted 1H-benzimidazole-4-carboxamides are potent PARP inhibitors | ABBVIE INC. | 2011-08-16 | — | — | US | disclosed |
| US-20090186877-A1 | SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS | ABBOTT LABORATORIES (US) | 2009-07-23 | — | — | US | disclosed |
| US-20070259937-A1 | SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS | ABBOTT LABORATORIES | 2007-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259937-A1 | SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS | PARP1, PARP2, PARP4 | CYP2B6 912/4885HSD11B1 3344/4885HPGD 774/4885 |
| US-20090186877-A1 | SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS | PARP1, PARP2, PARP4 | CYP2B6 912/4885HSD11B1 3344/4885HPGD 774/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.