Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.31 |
| ▸ | HTR2C | P28335 | 2/20 | 0.31 |
| ▸ | HTR2B | P41595 | 2/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3117365 | 0.83 | SLC6A2 (0.64) | SLC6A2SLC6A3SLC6A4HTR1A | |
| SCHEMBL3121315 | 0.81 | SLC6A2 (0.41) | SLC6A2SLC6A3SLC6A4SCN9AHTR1A | |
| SCHEMBL22296699 | 0.78 | SLC6A2 (0.44) | SLC6A2SLC6A3SLC6A4HTR1A | |
| SCHEMBL2300405 | 0.77 | SLC6A4 (0.71) | SLC6A2SLC6A3SLC6A4HTR2CHTR2B | |
| SCHEMBL2299025 | 0.77 | FPR2 (0.44) | SLC6A4HTR2CHTR2B | |
| SCHEMBL2299176 | 0.76 | GRIN1 (0.40) | — | |
| SCHEMBL22283713 | 0.76 | SLC6A4 (0.42) | SLC6A2SLC6A3SLC6A4SCN9AHTR2A | |
| SCHEMBL22283717 | 0.76 | SLC6A4 (0.42) | SLC6A2SLC6A3SLC6A4SCN9AHTR2A | |
| SCHEMBL2299164 | 0.76 | SLC6A2 (0.37) | SLC6A2SLC6A3SLC6A4SCN9AHTR1A | |
| SCHEMBL2300625 | 0.74 | SLC6A2 (0.50) | SLC6A2SLC6A3SLC6A4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2536689-A1 | ARYL CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS FOR TREATMENT OF PAIN | Amgen Inc. (US) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011103196-A1 | ARYL CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS FOR TREATMENT OF PAIN | AMGEN INC. (US) | 2011-08-25 | — | — | WO | disclosed |