Sugi Predict

Sugi Predict / Compounds / SCHEMBL22975718

SCHEMBL22975718

SCHEMBL22975718

CC1(C)O[C@@H]2[C@H](O1)[C@@H](CO)O[C@H]2n1ccc2c(OC(=O)NC3CCCC3)nc(Cl)nc21

nearest known ligand 0.40

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ ADORA1 P30542 5/20 0.38
▸ ADORA2A P29274 4/20 0.38
▸ ADORA3 P0DMS8 4/20 0.38
▸ ADORA2B P29275 3/20 0.38
▸ MEN1 O00255 1/20 0.38
▸ CYP1A2 P05177 1/20 0.38
▸ MAPK1 P28482 1/20 0.38
▸ KMT2A Q03164 1/20 0.38
▸ ALOX15 P16050 1/20 0.38
▸ RXFP1 Q9HBX9 1/20 0.37
▸ PI4KA P42356 1/20 0.37
▸ PI4K2B Q8TCG2 1/20 0.37
▸ PI4K2A Q9BTU6 1/20 0.37
▸ PI4KB Q9UBF8 1/20 0.37
▸ HTR2C P28335 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22975679 0.86 NT5E (0.43) —
SCHEMBL22975612 0.86 NT5E (0.36) ADORA1ADORA2AADORA3ADORA2B
SCHEMBL21839631 0.83 ADORA3 (0.50) ADORA1ADORA2AADORA3ADORA2BMEN1
SCHEMBL22975547 0.79 NT5E (0.42) —
SCHEMBL26721186 0.78 PI4KA (0.41) ADORA1ADORA2AADORA3ADORA2BMEN1
SCHEMBL21882955 0.78 PI4KA (0.47) ADORA2AKMT2API4KAPI4K2BPI4K2A
SCHEMBL18572205 0.78 PI4KA (0.47) ADORA2AKMT2API4KAPI4K2BPI4K2A
SCHEMBL22975716 0.77 PI4KA (0.38) ADORA1ADORA2AADORA3ADORA2BMEN1
SCHEMBL24618971 0.77 ADORA3 (0.46) ADORA1ADORA2AADORA3ADORA2BMEN1
SCHEMBL22614471 0.76 PI4KA (0.41) ADORA1ADORA2AADORA3ADORA2BMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240124512-A1 CD73 INHIBITORS ORIC PHARMACEUTICALS, INC. 2024-04-18 — — US disclosed
US-11807658-B2 CD73 inhibitors ORIC PHARMACEUTICALS, INC. (US) 2023-11-07 — — US disclosed
US-20220220147-A1 CD73 INHIBITORS ORIC PHARMACEUTICALS, INC. 2022-07-14 — — US disclosed
US-11325938-B2 CD73 inhibitors ORIC PHARMACEUTICALS, INC. (US) 2022-05-10 — — US disclosed
EP-3787635-A1 CD73 INHIBITORS Oric Pharmaceuticals, Inc. (US) 2021-03-10 — — EP disclosed
US-20210047359-A1 CD73 INHIBITORS ORIC PHARMACEUTICALS, INC. 2021-02-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240124512-A1 CD73 INHIBITORS ENTPD5, NT5E, ENTPD1 ADORA1 23/4885ADORA2A 11/4885ADORA3 19/4885
US-11807658-B2 CD73 inhibitors ENTPD5, NT5E, ENTPD1 ADORA1 23/4885ADORA2A 11/4885ADORA3 19/4885
US-20220220147-A1 CD73 INHIBITORS ENTPD5, NT5E, ENTPD1 ADORA1 23/4885ADORA2A 11/4885ADORA3 19/4885
US-11325938-B2 CD73 inhibitors ENTPD5, NT5E, ENTPD1 ADORA1 23/4885ADORA2A 11/4885ADORA3 19/4885
US-20210047359-A1 CD73 INHIBITORS ENTPD5, NT5E, ENTPD1 ADORA1 23/4885ADORA2A 11/4885ADORA3 19/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.