Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.46 |
| ▸ | ACACB | O00763 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 3/20 | 0.36 |
| ▸ | APP | P05067 | 2/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2358834 | 0.85 | GPR3 (0.38) | MAOBSMN1; SMN2BACE1KDM4CSCN9A | |
| SCHEMBL15839757 | 0.80 | TSHR (0.51) | MAOBACACBHRH3SMN1; SMN2NPC1 | |
| SCHEMBL2302727 | 0.79 | PPARG (0.40) | HRH3SMN1; SMN2NPC1NFKB1RAB9A | |
| SCHEMBL5107236 | 0.79 | HRH3 (0.63) | HRH3SMN1; SMN2 | |
| SCHEMBL2302335 | 0.77 | GPR3 (0.39) | ACACBSMN1; SMN2NPC1NFKB1RAB9A | |
| SCHEMBL17585106 | 0.75 | HRH3 (0.59) | MAOBACACBHRH3HRH1 | |
| SCHEMBL9882628 | 0.74 | MAOB (0.48) | MAOBACACBHRH3BACE1APP | |
| SCHEMBL30205888 | 0.73 | HRH3 (0.53) | MAOBACACBHRH3SMN1; SMN2NPC1 | |
| SCHEMBL2090651 | 0.72 | TRPV1 (0.38) | HRH3SCN9ATSHR | |
| SCHEMBL2094044 | 0.72 | PDE4B (0.46) | MAOBSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2536689-A1 | ARYL CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS FOR TREATMENT OF PAIN | Amgen Inc. (US) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011103196-A1 | ARYL CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS FOR TREATMENT OF PAIN | AMGEN INC. (US) | 2011-08-25 | — | — | WO | disclosed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |