SCHEMBL22977551

SCHEMBL22977551

C#Cc1ccc(CN(CCOC(=O)O[C@H]2C[C@H](n3cc(C#CCNC(=O)C(F)(F)F)c(=O)[nH]c3=O)O[C@@H]2CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)CC2CCCCN2C(=O)O)cc1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30932973 0.96 — —
SCHEMBL22288092 0.96 — —
SCHEMBL22288102 0.92 RNASE1 (0.31) —
SCHEMBL22977554 0.89 RNASE1 (0.39) —
SCHEMBL22288090 0.88 — —
SCHEMBL30932969 0.88 — —
SCHEMBL22288113 0.85 — —
SCHEMBL30932972 0.84 RNASE1 (0.38) —
SCHEMBL20535951 0.84 RNASE1 (0.42) —
SCHEMBL20535919 0.84 RNASE1 (0.42) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240199681-A1 OLIGONUCLEOTIDE AND NUCLEIC ACID SYNTHESIS EVONETIX LTD (GB) 2024-06-20 — — US disclosed
US-11161869-B2 Thermally-cleavable protecting and linker groups EVONETIX LTD. (GB) 2021-11-02 — — US disclosed
US-20210107934-A1 THERMALLY-CLEAVABLE PROTECTING AND LINKER GROUPS SILICON VALLEY BANK 2021-04-15 — — US disclosed
US-20210047361-A1 OLIGONUCLEOTIDE AND NUCLEIC ACID SYNTHESIS SILICON VALLEY BANK 2021-02-18 — — US disclosed
Send feedback