Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 2/20 | 0.56 |
| ▸ | FNTA | P49354 | 1/20 | 0.38 |
| ▸ | FNTB | P49356 | 1/20 | 0.38 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.38 |
| ▸ | CASR | P41180 | 2/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | BMP1 | P13497 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6658144 | 0.94 | CXCR4 (0.61) | CXCR4FNTAFNTBPGGT1BCASR | |
| SCHEMBL6653628 | 0.94 | CXCR4 (0.56) | CXCR4FNTAFNTBPGGT1BCASR | |
| SCHEMBL6657942 | 0.93 | CXCR4 (0.56) | CXCR4FNTAFNTBPGGT1BCASR | |
| SCHEMBL6653234 | 0.93 | CXCR4 (0.56) | CXCR4FNTAFNTBPGGT1BCASR | |
| SCHEMBL6657509 | 0.93 | CXCR4 (0.58) | CXCR4FNTAFNTBPGGT1BCASR | |
| SCHEMBL6654211 | 0.92 | CXCR4 (0.56) | CXCR4FNTAFNTBPGGT1BCASR | |
| SCHEMBL6657686 | 0.91 | CXCR4 (0.54) | CXCR4FNTAFNTBPGGT1BCASR | |
| SCHEMBL6653387 | 0.91 | CXCR4 (0.54) | CXCR4FNTAFNTBPGGT1BCASR | |
| SCHEMBL6655131 | 0.91 | CXCR4 (0.54) | CXCR4FNTAFNTBPGGT1BCASR | |
| SCHEMBL6655264 | 0.91 | CXCR4 (0.55) | CXCR4FNTAFNTBPGGT1BCASR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1993584-A2 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF OPHTHALMIC DISEASE | Allergan, Inc. (US) | 2008-11-26 | — | — | EP | claimed |
| WO-2008029276-A2 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF OPHTHALMIC DISEASE | ALLERGAN, INC. (US) | 2008-03-13 | — | — | WO | claimed |
| US-20070203089-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF OPHTHALMIC DISEASE | ALLERGAN, INC. | 2007-08-30 | — | — | US | claimed |
| US-20040254221-A1 | Novel Nitrogenous Compound and use thereof | KUREHA CORPORATION (JP) | 2004-12-16 | — | — | US | claimed |
| EP-1431290-A1 | NOVEL NITROGENOUS COMPOUND AND USE THEREOF | Kureha Chemical Industry Co., Ltd. (JP) | 2004-06-23 | — | — | EP | claimed |
| EP-1993584-B1 | Inhibitors of CXCR4 activity for use in the treatment of ocular disorders | ALLERGAN INC (US) | 2012-05-30 | — | — | EP | disclosed |
| EP-2407171-A2 | Compositions and methods for the treatment of ophthalmic disease | Allergan, Inc. (US) | 2012-01-18 | — | — | EP | disclosed |
| US-20120003275-A1 | Compositions and Methods for the Treatment of Ophthalmic Disease | ALLERGAN, INC. | 2012-01-05 | — | — | US | disclosed |
| EP-2397148-A2 | Compositions and methods for the treatment of ophthalmic disease | Allergan, Inc. (US) | 2011-12-21 | — | — | EP | disclosed |
| US-7964191-B2 | Compositions and methods for the treatment of ophthalmic disease | ALLERGAN, INC. (US) | 2011-06-21 | — | — | US | disclosed |
| EP-1993584-A2 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF OPHTHALMIC DISEASE | Allergan, Inc. (US) | 2008-11-26 | — | — | EP | disclosed |
| WO-2008029276-A2 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF OPHTHALMIC DISEASE | ALLERGAN, INC. (US) | 2008-03-13 | — | — | WO | disclosed |
| US-20070203089-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF OPHTHALMIC DISEASE | ALLERGAN, INC. | 2007-08-30 | — | — | US | disclosed |
| US-20040254221-A1 | Novel Nitrogenous Compound and use thereof | KUREHA CORPORATION (JP) | 2004-12-16 | — | — | US | disclosed |
| EP-1431290-A1 | NOVEL NITROGENOUS COMPOUND AND USE THEREOF | Kureha Chemical Industry Co., Ltd. (JP) | 2004-06-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120003275-A1 | Compositions and Methods for the Treatment of Ophthalmic Disease | CXCL12, CXCR4, PDE6C | CXCR4 2/4885FNTA 3653/4885FNTB 3417/4885 |
| US-20040254221-A1 | Novel Nitrogenous Compound and use thereof | NGLY1, NOD1, CCR1 | CXCR4 88/4885FNTA 2530/4885FNTB 1873/4885 |
| US-20070203089-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF OPHTHALMIC DISEASE | CXCL12, CXCR4, PDE6C | CXCR4 2/4885FNTA 3653/4885FNTB 3417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.