Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 1/20 | 0.49 |
| ▸ | MAP3K5 | Q99683 | 3/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 3/20 | 0.37 |
| ▸ | NOS1 | P29475 | 3/20 | 0.37 |
| ▸ | NOS2 | P35228 | 3/20 | 0.37 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.37 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.34 |
| ▸ | HTR2C | P28335 | 3/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.34 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22822736 | 0.77 | MAP3K5 (0.41) | MAP3K5HTR2AHTR2CCYP19A1LNPEP | |
| SCHEMBL23346741 | 0.77 | PIK3CB (0.73) | PIK3CBPDPK1FGFR1SRCNOS3 | |
| SCHEMBL29776556 | 0.75 | PIK3CB (0.39) | PIK3CBPDPK1FGFR1SRC | |
| SCHEMBL26638261 | 0.74 | TTBK1 (0.44) | PIK3CBPDPK1FGFR1SRCNOS3 | |
| SCHEMBL3345985 | 0.73 | PRKCI (0.44) | HTR2AHTR2C | |
| SCHEMBL26596987 | 0.72 | PIK3CB (0.49) | PIK3CBPDPK1FGFR1SRCNOS3 | |
| SCHEMBL26618797 | 0.72 | PIK3CB (0.49) | PIK3CBPDPK1FGFR1SRCNOS3 | |
| SCHEMBL6640906 | 0.72 | BTK (0.61) | PIK3CBFGFR1SRC | |
| SCHEMBL2298868 | 0.71 | MAP3K5 (0.50) | MAP3K5 | |
| SCHEMBL28017755 | 0.71 | MAP3K5 (0.61) | MAP3K5SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9403819-B2 | Apoptosis signal-regulating kinase 1 inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-08-02 | — | — | US | disclosed |
| CN-102834393-B | Apoptosis signal-regulating kinase 1 inhibitors | TAKEDA PHARMACEUTICAL | 2015-07-22 | — | — | CN | disclosed |
| US-20140329850-A1 | APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS | TAKEDA CALIFORNIA, INC. | 2014-11-06 | — | — | US | disclosed |
| US-8802695-B2 | Apoptosis signal-regulating kinase 1 inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-08-12 | — | — | US | disclosed |
| EP-2531501-B1 | APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS | TAKEDA PHARMACEUTICAL (JP) | 2013-11-20 | — | — | EP | disclosed |
| CN-102834393-A | Apoptosis signal-regulating kinase 1 inhibitors | TAKEDA PHARMACEUTICAL CORP | 2012-12-19 | — | — | CN | disclosed |
| US-20120316194-A1 | APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-12-13 | — | — | US | disclosed |
| EP-2531501-A1 | APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2012-12-12 | — | — | EP | disclosed |
| WO-2011097079-A1 | APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-08-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140329850-A1 | APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS | BAX, BCL2, BAD | PIK3CB 506/4885MAP3K5 8/4885PDPK1 102/4885 |
| US-20120316194-A1 | APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS | BAX, BCL2, BAD | PIK3CB 506/4885MAP3K5 8/4885PDPK1 102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.