Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.61 |
| ▸ | CDK4 | P11802 | 14/20 | 0.47 |
| ▸ | CCND1 | P24385 | 14/20 | 0.47 |
| ▸ | CCND2 | P30279 | 14/20 | 0.47 |
| ▸ | CCND3 | P30281 | 14/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.43 |
| ▸ | SRC | P12931 | 2/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.43 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22538172 | 0.84 | BTK (0.64) | BTKCDK4CCND1CCND2CCND3 | |
| SCHEMBL17119621 | 0.81 | BTK (0.58) | BTKCDK4CCND1CCND2CCND3 | |
| SCHEMBL6641014 | 0.81 | BTK (0.58) | BTKCDK4CCND1CCND2CCND3 | |
| SCHEMBL28282109 | 0.79 | BTK (0.70) | BTKCDK4CCND1CCND2CCND3 | |
| SCHEMBL6641536 | 0.76 | BTK (0.70) | BTKCDK4CCND1CCND2CCND3 | |
| SCHEMBL16964121 | 0.76 | BTK (1.00) | BTKSRC | |
| SCHEMBL6639654 | 0.76 | BTK (0.68) | BTKCDK4CCND1CCND2CCND3 | |
| SCHEMBL35211872 | 0.75 | BTK (0.50) | BTKCDK4CCND1CCND2CCND3 | |
| SCHEMBL17119629 | 0.74 | BTK (0.78) | BTKCDK4CCND1CCND2CCND3 | |
| SCHEMBL6641887 | 0.74 | BTK (0.67) | BTKCDK4CCND1CCND2CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003745-B1 | NAPHTHYRIDINONES FOR INHIBITING PROTEIN TYROSINE KINASE AND CELL CYCLE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2004-12-29 | — | — | EP | claimed |
| US-6150359-A | 1,6-NAPHTHYRIDIONE COMPOUNDS USEFUL FOR TREATING CANCER, RESTENOSIS AND ATHEROSCLEROSIS | WARNER-LAMBERT COMPANY (US) | 2000-11-21 | — | — | US | claimed |
| EP-1003745-A1 | NAPHTHYRIDINONES FOR INHIBITING PROTEIN TYROSINE KINASE AND CELL CYCLE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY LLC (US) | 2000-05-31 | — | — | EP | claimed |
| WO-1999009030-A1 | NAPHTHYRIDINONES FOR INHIBITING PROTEIN TYROSINE KINASE AND CELL CYCLE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1999-02-25 | — | — | WO | claimed |
| EP-1003745-B1 | NAPHTHYRIDINONES FOR INHIBITING PROTEIN TYROSINE KINASE AND CELL CYCLE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2004-12-29 | — | — | EP | disclosed |
| US-6150359-A | 1,6-NAPHTHYRIDIONE COMPOUNDS USEFUL FOR TREATING CANCER, RESTENOSIS AND ATHEROSCLEROSIS | WARNER-LAMBERT COMPANY (US) | 2000-11-21 | — | — | US | disclosed |
| EP-1003745-A1 | NAPHTHYRIDINONES FOR INHIBITING PROTEIN TYROSINE KINASE AND CELL CYCLE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY LLC (US) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999009030-A1 | NAPHTHYRIDINONES FOR INHIBITING PROTEIN TYROSINE KINASE AND CELL CYCLE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1999-02-25 | — | — | WO | disclosed |