Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | HTR2A | P28223 | 3/20 | 0.50 |
| ▸ | HTR2C | P28335 | 3/20 | 0.50 |
| ▸ | HTR7 | P34969 | 2/20 | 0.50 |
| ▸ | HTR6 | P50406 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL229811 | 1.00 | SMN1; SMN2 (0.50) | SMN1; SMN2LMNAHTR2AHTR2CHTR7 | |
| SCHEMBL224604 | 0.87 | HTR2A (0.57) | SMN1; SMN2LMNAHTR2AHTR2CHTR7 | |
| SCHEMBL224605 | 0.87 | HTR2A (0.57) | SMN1; SMN2LMNAHTR2AHTR2CHTR7 | |
| SCHEMBL28775592 | 0.86 | HTR2C (0.56) | SMN1; SMN2LMNAHTR2AHTR2CHTR7 | |
| SCHEMBL228799 | 0.86 | HTR2A (0.56) | SMN1; SMN2LMNAHTR2AHTR2CHTR7 | |
| SCHEMBL337834 | 0.85 | HTR2A (0.51) | SMN1; SMN2LMNAHTR2AHTR2CHTR7 | |
| SCHEMBL337835 | 0.85 | HTR2A (0.51) | SMN1; SMN2LMNAHTR2AHTR2CHTR7 | |
| SCHEMBL1923302 | 0.85 | HTR2A (0.51) | SMN1; SMN2LMNAHTR2AHTR2CHTR7 | |
| SCHEMBL227239 | 0.85 | HTR2A (0.55) | SMN1; SMN2LMNAHTR2AHTR2CHTR7 | |
| SCHEMBL229450 | 0.85 | HTR2A (0.55) | SMN1; SMN2LMNAHTR2AHTR2CHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8415350-B2 | Benzoyl-piperidine derivatives as dual modulators of the 5-HT2A and D3 receptors | HOFFMANN-LA ROCHE INC. (US) | 2013-04-09 | — | — | US | disclosed |
| US-20120004208-A1 | BENZOYL-PIPERIDINE DERIVATIVES AS DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | GOBBI LUCA (CH) | 2012-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120004208-A1 | BENZOYL-PIPERIDINE DERIVATIVES AS DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | HTR2A, HTR3A, HTR2C | SMN1; SMN2 3058/4885LMNA 3403/4885HTR2A 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.