SCHEMBL2298113

SCHEMBL2298113

O=C(O)C1CCC2(CCOCC2)C1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 2/20 0.48
TSHR P16473 3/20 0.46
GRM2 Q14416 2/20 0.46
GRM3 Q14832 2/20 0.46
GRM4 Q14833 2/20 0.46
CYP1A2 P05177 2/20 0.46
ALOX15 P16050 2/20 0.46
TDP1 Q9NUW8 1/20 0.46
GRM8 O00222 1/20 0.46
GRM6 O15303 1/20 0.46
LMNA P02545 1/20 0.46
GRM5 P41594 1/20 0.46
MTOR P42345 1/20 0.46
GRM1 Q13255 1/20 0.46
PLCB1 Q9NQ66 1/20 0.46
APLNR P35414 1/20 0.35
HRH3 Q9Y5N1 5/20 0.35
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
GABRP O00591 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29059275 0.85 CYP2C19 (0.61) CYP2C19TSHRGRM2GRM3GRM4
SCHEMBL9977512 0.85 CYP2C19 (0.59) CYP2C19TSHRGRM2GRM3GRM4
SCHEMBL25855066 0.85 CYP2C19 (0.59) CYP2C19TSHRGRM2GRM3GRM4
SCHEMBL11646566 0.83 CYP2C19 (0.62) CYP2C19TSHRGRM2GRM3GRM4
SCHEMBL3021254 0.81 CYP2C19 (0.54) CYP2C19TSHRGRM2GRM3GRM4
SCHEMBL31332713 0.81 CYP2C19 (0.54) CYP2C19TSHRGRM2GRM3GRM4
SCHEMBL4072778 0.79 CYP2C19 (0.52) CYP2C19TSHRGRM2GRM3GRM4
SCHEMBL21570248 0.78 CYP2C19 (0.56) CYP2C19TSHRGRM2GRM3GRM4
SCHEMBL1433252 0.76 TSHR (0.50) CYP2C19TSHRGRM2GRM3GRM4
SCHEMBL31506997 0.73 CYP2C19 (0.50) CYP2C19TSHRGRM2GRM3GRM4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2675811-A1 TRICYCLIC PYRIDINE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PREPARATION Boehringer Ingelheim International GmbH (DE) 2013-12-25 EP disclosed
WO-2012110599-A1 TRICYCLIC PYRIDINE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PREPARATION BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-08-23 WO disclosed
WO-2011101424-A1 TRICYCLIC PYRIDINE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PREPARATION BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-08-25 WO disclosed