Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 11/20 | 0.47 |
| ▸ | KLKB1 | P03952 | 9/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22981213 | 0.92 | F11 (0.45) | F11KLKB1 | |
| SCHEMBL22982359 | 0.89 | F11 (0.56) | F11KLKB1 | |
| SCHEMBL29405107 | 0.89 | F11 (0.56) | F11KLKB1 | |
| SCHEMBL29388404 | 0.88 | NR1H2 (0.49) | F11KLKB1 | |
| SCHEMBL22993173 | 0.88 | NR1H2 (0.49) | F11KLKB1 | |
| SCHEMBL29405481 | 0.86 | F11 (0.52) | F11KLKB1 | |
| SCHEMBL24253253 | 0.85 | KLKB1 (0.47) | F11KLKB1 | |
| SCHEMBL26227494 | 0.85 | KLKB1 (0.46) | F11KLKB1 | |
| SCHEMBL22993238 | 0.82 | HDAC1 (0.46) | F11KLKB1 | |
| Lithium SCHEMBL29407575 | 0.81 | F11 (0.54) | F11KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4010333-A1 | PLASMA KALLIKREIN INHIBITORS | Kalvista Pharmaceuticals Limited (GB) | 2022-06-15 | — | — | EP | disclosed |
| WO-2021028645-A1 | PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2021-02-18 | — | — | WO | disclosed |
| WO-2021028649-A1 | PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2021-02-18 | — | — | WO | disclosed |