Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 16/20 | 1.00 |
| ▸ | F11 | P03951 | 6/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29407277 | 1.00 | KLKB1 (1.00) | KLKB1F11 | |
| SCHEMBL29405873 | 0.89 | KLKB1 (1.00) | KLKB1F11 | |
| SCHEMBL26227507 | 0.88 | KLKB1 (0.84) | KLKB1F11 | |
| SCHEMBL29407375 | 0.87 | KLKB1 (1.00) | KLKB1F11 | |
| SCHEMBL22982176 | 0.87 | KLKB1 (1.00) | KLKB1F11 | |
| Hydrochloric Acid SCHEMBL22981758 | 0.86 | KLKB1 (0.99) | KLKB1F11 | |
| Hydrochloric Acid SCHEMBL29407594 | 0.86 | KLKB1 (0.99) | KLKB1F11 | |
| SCHEMBL29407527 | 0.86 | KLKB1 (1.00) | KLKB1F11 | |
| SCHEMBL29407426 | 0.86 | KLKB1 (1.00) | KLKB1F11 | |
| SCHEMBL29407285 | 0.86 | F11 (0.87) | KLKB1F11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4010333-A1 | PLASMA KALLIKREIN INHIBITORS | Kalvista Pharmaceuticals Limited (GB) | 2022-06-15 | — | — | EP | disclosed |
| WO-2021028649-A1 | PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2021-02-18 | — | — | WO | disclosed |
| WO-2021028645-A1 | PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2021-02-18 | — | — | WO | disclosed |