Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.50 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.50 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1106964 | 0.82 | HDAC1 (0.62) | LMNAHDAC1HDAC6SMN1; SMN2NPC1 | |
| SCHEMBL1135419 | 0.81 | EPHX2 (0.54) | LMNAHDAC1HDAC6SMN1; SMN2NPC1 | |
| SCHEMBL11868047 | 0.81 | HDAC1 (0.61) | LMNAHDAC1HDAC6SMN1; SMN2NPC1 | |
| SCHEMBL1388177 | 0.81 | HDAC1 (0.61) | LMNAHDAC1HDAC6SMN1; SMN2NPC1 | |
| SCHEMBL4869573 | 0.81 | HDAC1 (0.61) | LMNAHDAC1HDAC6SMN1; SMN2NPC1 | |
| SCHEMBL31125745 | 0.80 | SMN1; SMN2 (0.50) | LMNAHDAC1HDAC6SMN1; SMN2NPC1 | |
| SCHEMBL30664584 | 0.80 | SMN1; SMN2 (0.50) | LMNAHDAC1HDAC6SMN1; SMN2NPC1 | |
| SCHEMBL30771879 | 0.80 | SMN1; SMN2 (0.50) | LMNAHDAC1HDAC6SMN1; SMN2NPC1 | |
| SCHEMBL21922025 | 0.80 | HDAC1 (0.59) | LMNAHDAC1HDAC6SMN1; SMN2NPC1 | |
| SCHEMBL28285906 | 0.79 | HDAC1 (0.62) | LMNAHDAC1HDAC6SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4013748-A1 | NONPEPTIDE SOMATOSTATIN TYPE 5 RECEPTOR AGONISTS AND USES THEREOF | Crinetics Pharmaceuticals, Inc. (US) | 2022-06-22 | — | — | EP | disclosed |
| CN-114585614-A | Non-peptide somatostatin type 5 receptor agonists and uses thereof | 克林提克斯医药股份有限公司 | 2022-06-03 | — | — | CN | disclosed |
| WO-2021030262-A1 | NONPEPTIDE SOMATOSTATIN TYPE 5 RECEPTOR AGONISTS AND USES THEREOF | Crinetics Pharmaceuticals, Inc. (US) | 2021-02-18 | — | — | WO | disclosed |